Theory of thermal anomalies in the specific heat of lipid bilayers containing cholesterol

Research output: Contribution to journalJournal articlepeer-review

Standard

Theory of thermal anomalies in the specific heat of lipid bilayers containing cholesterol. / Ipsen, J. H.; Mouritsen, O. G.; Zuckermann, M. J.

In: Biophysical Journal, Vol. 56, No. 4, 1989, p. 661-667.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Ipsen, JH, Mouritsen, OG & Zuckermann, MJ 1989, 'Theory of thermal anomalies in the specific heat of lipid bilayers containing cholesterol', Biophysical Journal, vol. 56, no. 4, pp. 661-667. https://doi.org/10.1016/S0006-3495(89)82713-4

APA

Ipsen, J. H., Mouritsen, O. G., & Zuckermann, M. J. (1989). Theory of thermal anomalies in the specific heat of lipid bilayers containing cholesterol. Biophysical Journal, 56(4), 661-667. https://doi.org/10.1016/S0006-3495(89)82713-4

Vancouver

Ipsen JH, Mouritsen OG, Zuckermann MJ. Theory of thermal anomalies in the specific heat of lipid bilayers containing cholesterol. Biophysical Journal. 1989;56(4):661-667. https://doi.org/10.1016/S0006-3495(89)82713-4

Author

Ipsen, J. H. ; Mouritsen, O. G. ; Zuckermann, M. J. / Theory of thermal anomalies in the specific heat of lipid bilayers containing cholesterol. In: Biophysical Journal. 1989 ; Vol. 56, No. 4. pp. 661-667.

Bibtex

@article{e55d12a0e3ce425b98e0d725c8118946,
title = "Theory of thermal anomalies in the specific heat of lipid bilayers containing cholesterol",
abstract = "A theoretical explanation of the experimentally observed characteristic thermal anomalies in the specific heat of lipid bilayers containing cholesterol is provided in terms of the phase equilibria in the phosphatidylcholine-cholesterol system. The phase equilibria are calculated via a microscopic interaction model that takes proper account of both the conformational and the crystalline degrees of freedom of the lipid acyl chains. It is shown that the characteristic double-peaked specific heat, with a narrow and a broad component, is a natural consequence of the topology of the phase diagram. Some results for the enthalpy of the mixed system are also reported. It is suggested that there is no need for invoking special mechanisms such as lipid-cholesterol complexing or formation of special interfacial regions in the bilayer in order to explain the specific-heat anomalies.",
author = "Ipsen, {J. H.} and Mouritsen, {O. G.} and Zuckermann, {M. J.}",
year = "1989",
doi = "10.1016/S0006-3495(89)82713-4",
language = "English",
volume = "56",
pages = "661--667",
journal = "Biophysical Society. Annual Meeting. Abstracts",
issn = "0523-6800",
publisher = "Biophysical Society",
number = "4",

}

RIS

TY - JOUR

T1 - Theory of thermal anomalies in the specific heat of lipid bilayers containing cholesterol

AU - Ipsen, J. H.

AU - Mouritsen, O. G.

AU - Zuckermann, M. J.

PY - 1989

Y1 - 1989

N2 - A theoretical explanation of the experimentally observed characteristic thermal anomalies in the specific heat of lipid bilayers containing cholesterol is provided in terms of the phase equilibria in the phosphatidylcholine-cholesterol system. The phase equilibria are calculated via a microscopic interaction model that takes proper account of both the conformational and the crystalline degrees of freedom of the lipid acyl chains. It is shown that the characteristic double-peaked specific heat, with a narrow and a broad component, is a natural consequence of the topology of the phase diagram. Some results for the enthalpy of the mixed system are also reported. It is suggested that there is no need for invoking special mechanisms such as lipid-cholesterol complexing or formation of special interfacial regions in the bilayer in order to explain the specific-heat anomalies.

AB - A theoretical explanation of the experimentally observed characteristic thermal anomalies in the specific heat of lipid bilayers containing cholesterol is provided in terms of the phase equilibria in the phosphatidylcholine-cholesterol system. The phase equilibria are calculated via a microscopic interaction model that takes proper account of both the conformational and the crystalline degrees of freedom of the lipid acyl chains. It is shown that the characteristic double-peaked specific heat, with a narrow and a broad component, is a natural consequence of the topology of the phase diagram. Some results for the enthalpy of the mixed system are also reported. It is suggested that there is no need for invoking special mechanisms such as lipid-cholesterol complexing or formation of special interfacial regions in the bilayer in order to explain the specific-heat anomalies.

U2 - 10.1016/S0006-3495(89)82713-4

DO - 10.1016/S0006-3495(89)82713-4

M3 - Journal article

C2 - 2819232

AN - SCOPUS:0024740905

VL - 56

SP - 661

EP - 667

JO - Biophysical Society. Annual Meeting. Abstracts

JF - Biophysical Society. Annual Meeting. Abstracts

SN - 0523-6800

IS - 4

ER -

ID: 238387470