Theory of protein-induced lateral phase separation in lipid membranes

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Theory of protein-induced lateral phase separation in lipid membranes. / Sperotto, Maria M.; Ipsen, John Hjort; Mouritsen, Ole G.

In: Cell Biochemistry and Biophysics, Vol. 14, No. 1, 1989, p. 79-95.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Sperotto, MM, Ipsen, JH & Mouritsen, OG 1989, 'Theory of protein-induced lateral phase separation in lipid membranes', Cell Biochemistry and Biophysics, vol. 14, no. 1, pp. 79-95. https://doi.org/10.1007/BF02797393

APA

Sperotto, M. M., Ipsen, J. H., & Mouritsen, O. G. (1989). Theory of protein-induced lateral phase separation in lipid membranes. Cell Biochemistry and Biophysics, 14(1), 79-95. https://doi.org/10.1007/BF02797393

Vancouver

Sperotto MM, Ipsen JH, Mouritsen OG. Theory of protein-induced lateral phase separation in lipid membranes. Cell Biochemistry and Biophysics. 1989;14(1):79-95. https://doi.org/10.1007/BF02797393

Author

Sperotto, Maria M. ; Ipsen, John Hjort ; Mouritsen, Ole G. / Theory of protein-induced lateral phase separation in lipid membranes. In: Cell Biochemistry and Biophysics. 1989 ; Vol. 14, No. 1. pp. 79-95.

Bibtex

@article{ebbbda38f4244fb9ac3e4b24de5044ee,
title = "Theory of protein-induced lateral phase separation in lipid membranes",
abstract = "An account is given of the current status of theoretical modeling of the phase equilibria in lipid membranes with intrinsic proteins. Special attention is paid to the description of lateral phase separation, which is important for membrane function since it may lead to biologically differentiated regions. We discuss in particular the mattressmodel approach by Mouritsen and Bloom (37), who take matching between protein and lipid hydrophobic thicknesses as a determining factor for the phase behavior. The model has been developed in the framework of phenomenological thermodynamics solution theory. The predictions of the theory are compared to a variety of experimental measurements, including those of membrane recombinants of the protein content of the reaction center and antenna protein of the bacterial photosynthetic apparatus as well as the erythrocyte band 3 protein. The physical effects of lipid-protein interactions are contrasted to those of lipid-cholesterol interactions. The concept of hydrophobic matching is then used as a basis for discussing a possible relationship between membrane thickness and physiological function.",
keywords = "cholesterol, hydrophobic thickness, lipid membranes, Lipid-protein interactions, phase separation, phase transition, solution theory, statistical mechanics, thermodynamics",
author = "Sperotto, {Maria M.} and Ipsen, {John Hjort} and Mouritsen, {Ole G.}",
year = "1989",
doi = "10.1007/BF02797393",
language = "English",
volume = "14",
pages = "79--95",
journal = "Cell Biochemistry and Biophysics",
issn = "1085-9195",
publisher = "Humana Press",
number = "1",

}

RIS

TY - JOUR

T1 - Theory of protein-induced lateral phase separation in lipid membranes

AU - Sperotto, Maria M.

AU - Ipsen, John Hjort

AU - Mouritsen, Ole G.

PY - 1989

Y1 - 1989

N2 - An account is given of the current status of theoretical modeling of the phase equilibria in lipid membranes with intrinsic proteins. Special attention is paid to the description of lateral phase separation, which is important for membrane function since it may lead to biologically differentiated regions. We discuss in particular the mattressmodel approach by Mouritsen and Bloom (37), who take matching between protein and lipid hydrophobic thicknesses as a determining factor for the phase behavior. The model has been developed in the framework of phenomenological thermodynamics solution theory. The predictions of the theory are compared to a variety of experimental measurements, including those of membrane recombinants of the protein content of the reaction center and antenna protein of the bacterial photosynthetic apparatus as well as the erythrocyte band 3 protein. The physical effects of lipid-protein interactions are contrasted to those of lipid-cholesterol interactions. The concept of hydrophobic matching is then used as a basis for discussing a possible relationship between membrane thickness and physiological function.

AB - An account is given of the current status of theoretical modeling of the phase equilibria in lipid membranes with intrinsic proteins. Special attention is paid to the description of lateral phase separation, which is important for membrane function since it may lead to biologically differentiated regions. We discuss in particular the mattressmodel approach by Mouritsen and Bloom (37), who take matching between protein and lipid hydrophobic thicknesses as a determining factor for the phase behavior. The model has been developed in the framework of phenomenological thermodynamics solution theory. The predictions of the theory are compared to a variety of experimental measurements, including those of membrane recombinants of the protein content of the reaction center and antenna protein of the bacterial photosynthetic apparatus as well as the erythrocyte band 3 protein. The physical effects of lipid-protein interactions are contrasted to those of lipid-cholesterol interactions. The concept of hydrophobic matching is then used as a basis for discussing a possible relationship between membrane thickness and physiological function.

KW - cholesterol

KW - hydrophobic thickness

KW - lipid membranes

KW - Lipid-protein interactions

KW - phase separation

KW - phase transition

KW - solution theory

KW - statistical mechanics

KW - thermodynamics

U2 - 10.1007/BF02797393

DO - 10.1007/BF02797393

M3 - Journal article

C2 - 2465088

AN - SCOPUS:0024400738

VL - 14

SP - 79

EP - 95

JO - Cell Biochemistry and Biophysics

JF - Cell Biochemistry and Biophysics

SN - 1085-9195

IS - 1

ER -

ID: 238387687