The Potential of Pectins to Modulate the Human Gut Microbiota Evaluated by In Vitro Fermentation: A Systematic Review

Research output: Contribution to journalReviewpeer-review

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The Potential of Pectins to Modulate the Human Gut Microbiota Evaluated by In Vitro Fermentation : A Systematic Review. / Pascale, Nélida; Gu, Fangjie; Larsen, Nadja; Jespersen, Lene; Respondek, Frederique.

In: Nutrients, Vol. 14, No. 17, 3629, 2022.

Research output: Contribution to journalReviewpeer-review

Harvard

Pascale, N, Gu, F, Larsen, N, Jespersen, L & Respondek, F 2022, 'The Potential of Pectins to Modulate the Human Gut Microbiota Evaluated by In Vitro Fermentation: A Systematic Review', Nutrients, vol. 14, no. 17, 3629. https://doi.org/10.3390/nu14173629

APA

Pascale, N., Gu, F., Larsen, N., Jespersen, L., & Respondek, F. (2022). The Potential of Pectins to Modulate the Human Gut Microbiota Evaluated by In Vitro Fermentation: A Systematic Review. Nutrients, 14(17), [3629]. https://doi.org/10.3390/nu14173629

Vancouver

Pascale N, Gu F, Larsen N, Jespersen L, Respondek F. The Potential of Pectins to Modulate the Human Gut Microbiota Evaluated by In Vitro Fermentation: A Systematic Review. Nutrients. 2022;14(17). 3629. https://doi.org/10.3390/nu14173629

Author

Pascale, Nélida ; Gu, Fangjie ; Larsen, Nadja ; Jespersen, Lene ; Respondek, Frederique. / The Potential of Pectins to Modulate the Human Gut Microbiota Evaluated by In Vitro Fermentation : A Systematic Review. In: Nutrients. 2022 ; Vol. 14, No. 17.

Bibtex

@article{60c7fffccdb940a0ab6e11fe489f11ad,
title = "The Potential of Pectins to Modulate the Human Gut Microbiota Evaluated by In Vitro Fermentation: A Systematic Review",
abstract = "Pectin is a dietary fiber, and its health effects have been described extensively. Although there are limited clinical studies, there is a growing body of evidence from in vitro studies investigating the effect of pectin on human gut microbiota. This comprehensive review summarizes the findings of gut microbiota modulation in vitro as assessed by 16S rRNA gene-based technologies and elucidates the potential structure-activity relationships. Generally, pectic substrates are slowly but completely fermented, with a greater production of acetate compared with other fibers. Their fermentation, either directly or by cross-feeding interactions, results in the increased abundances of gut bacterial communities such as the family of Ruminococcaceae, the Bacteroides and Lachnospira genera, and species such as Lachnospira eligens and Faecalibacterium prausnitzii, where the specific stimulation of Lachnospira and L. eligens is unique to pectic substrates. Furthermore, the degree of methyl esterification, the homogalacturonan-to-rhamnogalacturonan ratio, and the molecular weight are the most influential structural factors on the gut microbiota. The latter particularly influences the growth of Bifidobacterium spp. The prebiotic potential of pectin targeting specific gut bacteria beneficial for human health and well-being still needs to be confirmed in humans, including the relationship between its structural features and activity.",
keywords = "dietary fiber, gut health, human, microbiota, pectin, prebiotic",
author = "N{\'e}lida Pascale and Fangjie Gu and Nadja Larsen and Lene Jespersen and Frederique Respondek",
note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",
year = "2022",
doi = "10.3390/nu14173629",
language = "English",
volume = "14",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "17",

}

RIS

TY - JOUR

T1 - The Potential of Pectins to Modulate the Human Gut Microbiota Evaluated by In Vitro Fermentation

T2 - A Systematic Review

AU - Pascale, Nélida

AU - Gu, Fangjie

AU - Larsen, Nadja

AU - Jespersen, Lene

AU - Respondek, Frederique

N1 - Publisher Copyright: © 2022 by the authors.

PY - 2022

Y1 - 2022

N2 - Pectin is a dietary fiber, and its health effects have been described extensively. Although there are limited clinical studies, there is a growing body of evidence from in vitro studies investigating the effect of pectin on human gut microbiota. This comprehensive review summarizes the findings of gut microbiota modulation in vitro as assessed by 16S rRNA gene-based technologies and elucidates the potential structure-activity relationships. Generally, pectic substrates are slowly but completely fermented, with a greater production of acetate compared with other fibers. Their fermentation, either directly or by cross-feeding interactions, results in the increased abundances of gut bacterial communities such as the family of Ruminococcaceae, the Bacteroides and Lachnospira genera, and species such as Lachnospira eligens and Faecalibacterium prausnitzii, where the specific stimulation of Lachnospira and L. eligens is unique to pectic substrates. Furthermore, the degree of methyl esterification, the homogalacturonan-to-rhamnogalacturonan ratio, and the molecular weight are the most influential structural factors on the gut microbiota. The latter particularly influences the growth of Bifidobacterium spp. The prebiotic potential of pectin targeting specific gut bacteria beneficial for human health and well-being still needs to be confirmed in humans, including the relationship between its structural features and activity.

AB - Pectin is a dietary fiber, and its health effects have been described extensively. Although there are limited clinical studies, there is a growing body of evidence from in vitro studies investigating the effect of pectin on human gut microbiota. This comprehensive review summarizes the findings of gut microbiota modulation in vitro as assessed by 16S rRNA gene-based technologies and elucidates the potential structure-activity relationships. Generally, pectic substrates are slowly but completely fermented, with a greater production of acetate compared with other fibers. Their fermentation, either directly or by cross-feeding interactions, results in the increased abundances of gut bacterial communities such as the family of Ruminococcaceae, the Bacteroides and Lachnospira genera, and species such as Lachnospira eligens and Faecalibacterium prausnitzii, where the specific stimulation of Lachnospira and L. eligens is unique to pectic substrates. Furthermore, the degree of methyl esterification, the homogalacturonan-to-rhamnogalacturonan ratio, and the molecular weight are the most influential structural factors on the gut microbiota. The latter particularly influences the growth of Bifidobacterium spp. The prebiotic potential of pectin targeting specific gut bacteria beneficial for human health and well-being still needs to be confirmed in humans, including the relationship between its structural features and activity.

KW - dietary fiber

KW - gut health

KW - human

KW - microbiota

KW - pectin

KW - prebiotic

U2 - 10.3390/nu14173629

DO - 10.3390/nu14173629

M3 - Review

C2 - 36079886

AN - SCOPUS:85137554826

VL - 14

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 17

M1 - 3629

ER -

ID: 320874700