The impact of peptides on lipid membranes

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The impact of peptides on lipid membranes. / Khandelia, Himanshu; Ipsen, John H.; Mouritsen, Ole G.

In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1778, No. 7-8, 01.07.2008, p. 1528-1536.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Khandelia, H, Ipsen, JH & Mouritsen, OG 2008, 'The impact of peptides on lipid membranes', Biochimica et Biophysica Acta - Biomembranes, vol. 1778, no. 7-8, pp. 1528-1536. https://doi.org/10.1016/j.bbamem.2008.02.009

APA

Khandelia, H., Ipsen, J. H., & Mouritsen, O. G. (2008). The impact of peptides on lipid membranes. Biochimica et Biophysica Acta - Biomembranes, 1778(7-8), 1528-1536. https://doi.org/10.1016/j.bbamem.2008.02.009

Vancouver

Khandelia H, Ipsen JH, Mouritsen OG. The impact of peptides on lipid membranes. Biochimica et Biophysica Acta - Biomembranes. 2008 Jul 1;1778(7-8):1528-1536. https://doi.org/10.1016/j.bbamem.2008.02.009

Author

Khandelia, Himanshu ; Ipsen, John H. ; Mouritsen, Ole G. / The impact of peptides on lipid membranes. In: Biochimica et Biophysica Acta - Biomembranes. 2008 ; Vol. 1778, No. 7-8. pp. 1528-1536.

Bibtex

@article{c42c5dd1eb534909810255d66a1ab5bd,
title = "The impact of peptides on lipid membranes",
abstract = "We review the fundamental strategies used by small peptides to associate with lipid membranes and how the different strategies impact on the structure and dynamics of the lipids. In particular we focus on the binding of amphiphilic peptides by electrostatic and hydrophobic forces, on the anchoring of peptides to the bilayer by acylation and prenylation, and on the incorporation of small peptides that form well-defined channels. The effect of lipid-peptide interactions on the lipids is characterized in terms of lipid acyl-chain order, membrane thickness, membrane elasticity, permeability, lipid-domain and annulus formation, as well as acyl-chain dynamics. The different situations are illustrated by specific cases for which experimental observations can be interpreted and supplemented by theoretical modeling and simulations. A comparison is made with the effect on lipids of trans-membrane proteins. The various cases are discussed in the context of the possible roles played by lipid-peptide interactions for the biological, physiological, and pharmacological function of peptides.",
keywords = "Acylation, Antimicrobial peptide, Gramicidin A, Lipid-bilayer membrane, Molecular dynamics simulation, Prenylation",
author = "Himanshu Khandelia and Ipsen, {John H.} and Mouritsen, {Ole G.}",
year = "2008",
month = jul,
day = "1",
doi = "10.1016/j.bbamem.2008.02.009",
language = "English",
volume = "1778",
pages = "1528--1536",
journal = "B B A - Biomembranes",
issn = "0005-2736",
publisher = "Elsevier",
number = "7-8",

}

RIS

TY - JOUR

T1 - The impact of peptides on lipid membranes

AU - Khandelia, Himanshu

AU - Ipsen, John H.

AU - Mouritsen, Ole G.

PY - 2008/7/1

Y1 - 2008/7/1

N2 - We review the fundamental strategies used by small peptides to associate with lipid membranes and how the different strategies impact on the structure and dynamics of the lipids. In particular we focus on the binding of amphiphilic peptides by electrostatic and hydrophobic forces, on the anchoring of peptides to the bilayer by acylation and prenylation, and on the incorporation of small peptides that form well-defined channels. The effect of lipid-peptide interactions on the lipids is characterized in terms of lipid acyl-chain order, membrane thickness, membrane elasticity, permeability, lipid-domain and annulus formation, as well as acyl-chain dynamics. The different situations are illustrated by specific cases for which experimental observations can be interpreted and supplemented by theoretical modeling and simulations. A comparison is made with the effect on lipids of trans-membrane proteins. The various cases are discussed in the context of the possible roles played by lipid-peptide interactions for the biological, physiological, and pharmacological function of peptides.

AB - We review the fundamental strategies used by small peptides to associate with lipid membranes and how the different strategies impact on the structure and dynamics of the lipids. In particular we focus on the binding of amphiphilic peptides by electrostatic and hydrophobic forces, on the anchoring of peptides to the bilayer by acylation and prenylation, and on the incorporation of small peptides that form well-defined channels. The effect of lipid-peptide interactions on the lipids is characterized in terms of lipid acyl-chain order, membrane thickness, membrane elasticity, permeability, lipid-domain and annulus formation, as well as acyl-chain dynamics. The different situations are illustrated by specific cases for which experimental observations can be interpreted and supplemented by theoretical modeling and simulations. A comparison is made with the effect on lipids of trans-membrane proteins. The various cases are discussed in the context of the possible roles played by lipid-peptide interactions for the biological, physiological, and pharmacological function of peptides.

KW - Acylation

KW - Antimicrobial peptide

KW - Gramicidin A

KW - Lipid-bilayer membrane

KW - Molecular dynamics simulation

KW - Prenylation

UR - http://www.scopus.com/inward/record.url?scp=45449098245&partnerID=8YFLogxK

U2 - 10.1016/j.bbamem.2008.02.009

DO - 10.1016/j.bbamem.2008.02.009

M3 - Review

C2 - 18358231

AN - SCOPUS:45449098245

VL - 1778

SP - 1528

EP - 1536

JO - B B A - Biomembranes

JF - B B A - Biomembranes

SN - 0005-2736

IS - 7-8

ER -

ID: 230977385