The beneficial effect of acute exercise on motor memory consolidation is modulated by dopaminergic gene profile

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

The beneficial effect of acute exercise on motor memory consolidation is modulated by dopaminergic gene profile. / Christiansen, Lasse; Thomas, Richard; Beck, Mikkel Malling; Pingel, Jessica; Andersen, Jeppe Dyrberg; Mang, Cameron S; Madsen, Mads Alexander Just; Roig, Marc; Lundbye-Jensen, Jesper.

In: Journal of Clinical Medicine, Vol. 8, No. 5, 578, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Christiansen, L, Thomas, R, Beck, MM, Pingel, J, Andersen, JD, Mang, CS, Madsen, MAJ, Roig, M & Lundbye-Jensen, J 2019, 'The beneficial effect of acute exercise on motor memory consolidation is modulated by dopaminergic gene profile', Journal of Clinical Medicine, vol. 8, no. 5, 578. https://doi.org/10.3390/jcm8050578

APA

Christiansen, L., Thomas, R., Beck, M. M., Pingel, J., Andersen, J. D., Mang, C. S., ... Lundbye-Jensen, J. (2019). The beneficial effect of acute exercise on motor memory consolidation is modulated by dopaminergic gene profile. Journal of Clinical Medicine, 8(5), [578]. https://doi.org/10.3390/jcm8050578

Vancouver

Christiansen L, Thomas R, Beck MM, Pingel J, Andersen JD, Mang CS et al. The beneficial effect of acute exercise on motor memory consolidation is modulated by dopaminergic gene profile. Journal of Clinical Medicine. 2019;8(5). 578. https://doi.org/10.3390/jcm8050578

Author

Christiansen, Lasse ; Thomas, Richard ; Beck, Mikkel Malling ; Pingel, Jessica ; Andersen, Jeppe Dyrberg ; Mang, Cameron S ; Madsen, Mads Alexander Just ; Roig, Marc ; Lundbye-Jensen, Jesper. / The beneficial effect of acute exercise on motor memory consolidation is modulated by dopaminergic gene profile. In: Journal of Clinical Medicine. 2019 ; Vol. 8, No. 5.

Bibtex

@article{bb8f6eb9d6a0412388d7e26fe4f1eaeb,
title = "The beneficial effect of acute exercise on motor memory consolidation is modulated by dopaminergic gene profile",
abstract = "When aerobic exercise is performed following skilled motor practice, it can enhance motor memory consolidation. Previous studies have suggested that dopamine may play a role in motor memory consolidation, but whether it is involved in the exercise effects on consolidation is unknown. Hence, we aimed to investigate the influence of dopaminergic pathways on the exercise-induced modulation of motor memory consolidation. We compared the effect of acute exercise on motor memory consolidation between the genotypes that are known to affect dopaminergic transmission and learning. By combining cluster analyses and fitting linear models with and without included polymorphisms, we provide preliminary evidence that exercise benefits the carriers of alleles that are associated with low synaptic dopamine content. In line with previous reports, our findings implicate dopamine as a modulator of the exercise-induced effects on motor memory consolidation, and suggest exercise as a potential clinical tool to counteract low endogenous dopamine bioavailability. Further experiments are needed to establish causal relations.",
keywords = "Faculty of Science, Physical activity, Consolidation, Dopamine, Genetics, Motor learning, Single-nucleotide polymorphisms, Dopamine receptor",
author = "Lasse Christiansen and Richard Thomas and Beck, {Mikkel Malling} and Jessica Pingel and Andersen, {Jeppe Dyrberg} and Mang, {Cameron S} and Madsen, {Mads Alexander Just} and Marc Roig and Jesper Lundbye-Jensen",
note = "CURIS 2019 NEXS 149",
year = "2019",
doi = "10.3390/jcm8050578",
language = "English",
volume = "8",
journal = "Journal of Clinical Medicine",
issn = "2077-0383",
publisher = "M D P I AG",
number = "5",

}

RIS

TY - JOUR

T1 - The beneficial effect of acute exercise on motor memory consolidation is modulated by dopaminergic gene profile

AU - Christiansen, Lasse

AU - Thomas, Richard

AU - Beck, Mikkel Malling

AU - Pingel, Jessica

AU - Andersen, Jeppe Dyrberg

AU - Mang, Cameron S

AU - Madsen, Mads Alexander Just

AU - Roig, Marc

AU - Lundbye-Jensen, Jesper

N1 - CURIS 2019 NEXS 149

PY - 2019

Y1 - 2019

N2 - When aerobic exercise is performed following skilled motor practice, it can enhance motor memory consolidation. Previous studies have suggested that dopamine may play a role in motor memory consolidation, but whether it is involved in the exercise effects on consolidation is unknown. Hence, we aimed to investigate the influence of dopaminergic pathways on the exercise-induced modulation of motor memory consolidation. We compared the effect of acute exercise on motor memory consolidation between the genotypes that are known to affect dopaminergic transmission and learning. By combining cluster analyses and fitting linear models with and without included polymorphisms, we provide preliminary evidence that exercise benefits the carriers of alleles that are associated with low synaptic dopamine content. In line with previous reports, our findings implicate dopamine as a modulator of the exercise-induced effects on motor memory consolidation, and suggest exercise as a potential clinical tool to counteract low endogenous dopamine bioavailability. Further experiments are needed to establish causal relations.

AB - When aerobic exercise is performed following skilled motor practice, it can enhance motor memory consolidation. Previous studies have suggested that dopamine may play a role in motor memory consolidation, but whether it is involved in the exercise effects on consolidation is unknown. Hence, we aimed to investigate the influence of dopaminergic pathways on the exercise-induced modulation of motor memory consolidation. We compared the effect of acute exercise on motor memory consolidation between the genotypes that are known to affect dopaminergic transmission and learning. By combining cluster analyses and fitting linear models with and without included polymorphisms, we provide preliminary evidence that exercise benefits the carriers of alleles that are associated with low synaptic dopamine content. In line with previous reports, our findings implicate dopamine as a modulator of the exercise-induced effects on motor memory consolidation, and suggest exercise as a potential clinical tool to counteract low endogenous dopamine bioavailability. Further experiments are needed to establish causal relations.

KW - Faculty of Science

KW - Physical activity

KW - Consolidation

KW - Dopamine

KW - Genetics

KW - Motor learning

KW - Single-nucleotide polymorphisms

KW - Dopamine receptor

U2 - 10.3390/jcm8050578

DO - 10.3390/jcm8050578

M3 - Journal article

C2 - 31035583

VL - 8

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

SN - 2077-0383

IS - 5

M1 - 578

ER -

ID: 217379600