Taste alterations and oral discomfort in patients receiving chemotherapy
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Taste alterations and oral discomfort in patients receiving chemotherapy. / Larsen, Anne Kathrine; Thomsen, Christine; Sanden, Mathilde; Skadhauge, Lotte Boa; Anker, Camilla Bundgaard; Mortensen, Marie Nerup; Bredie, Wender L. P.
In: Supportive Care in Cancer, Vol. 29, 2021, p. 7431–7439.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Taste alterations and oral discomfort in patients receiving chemotherapy
AU - Larsen, Anne Kathrine
AU - Thomsen, Christine
AU - Sanden, Mathilde
AU - Skadhauge, Lotte Boa
AU - Anker, Camilla Bundgaard
AU - Mortensen, Marie Nerup
AU - Bredie, Wender L. P.
N1 - Funding Information: This work was financially supported by the Innovationsfonden (Denmark). Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2021
Y1 - 2021
N2 - Purpose: Taste alterations (TA) and oral discomfort in cancer patients are neglected side effects of the disease and treatments. They contribute to poor appetite, decrease food intake and affect quality of life, leading to adverse outcomes such as malnutrition and depression. The study aimed to explore TAs in relation to other oral conditions causing discomfort in cancer patients. Additionally, the correlation between patients’ acidity of saliva and experienced TAs and oral discomfort was evaluated. Methods: A case study including 100 patients diagnosed with cancer receiving chemotherapy or immunotherapy. Data were collected using two questionnaire forms: the Chemotherapy-induced Taste Alteration Scale (CiTAS) and an additional information questionnaire. Saliva samples were collected for each patient and measured with a pocket pH meter. Data were analysed using descriptive statistics, and comparisons were performed using the Kruskal–Wallis H test, Mann–Whitney U test and Fisher’s exact test. Results: The prevalence of reported TAs was 93%. Patient age, oral discomfort and swallowing difficulty were found to be significant factors for experienced TAs (p < 0.05). No correlation between patients’ acidity of saliva and reported TAs and oral discomfort was found. Conclusion: CiTAS proved to be a convenient tool to collect information about TAs in cancer patients. Using the CiTAS tool, a high prevalence (93%) of reported TAs in cancer patients receiving chemo- or immunotherapy was found. CiTAS provides a fast and cheap recognition of symptoms and causes of TAs that can be addressed.
AB - Purpose: Taste alterations (TA) and oral discomfort in cancer patients are neglected side effects of the disease and treatments. They contribute to poor appetite, decrease food intake and affect quality of life, leading to adverse outcomes such as malnutrition and depression. The study aimed to explore TAs in relation to other oral conditions causing discomfort in cancer patients. Additionally, the correlation between patients’ acidity of saliva and experienced TAs and oral discomfort was evaluated. Methods: A case study including 100 patients diagnosed with cancer receiving chemotherapy or immunotherapy. Data were collected using two questionnaire forms: the Chemotherapy-induced Taste Alteration Scale (CiTAS) and an additional information questionnaire. Saliva samples were collected for each patient and measured with a pocket pH meter. Data were analysed using descriptive statistics, and comparisons were performed using the Kruskal–Wallis H test, Mann–Whitney U test and Fisher’s exact test. Results: The prevalence of reported TAs was 93%. Patient age, oral discomfort and swallowing difficulty were found to be significant factors for experienced TAs (p < 0.05). No correlation between patients’ acidity of saliva and reported TAs and oral discomfort was found. Conclusion: CiTAS proved to be a convenient tool to collect information about TAs in cancer patients. Using the CiTAS tool, a high prevalence (93%) of reported TAs in cancer patients receiving chemo- or immunotherapy was found. CiTAS provides a fast and cheap recognition of symptoms and causes of TAs that can be addressed.
KW - Acidity
KW - Cancer
KW - Chemotherapy
KW - CiTAS
KW - PH
KW - Saliva
KW - Taste alterations
U2 - 10.1007/s00520-021-06316-4
DO - 10.1007/s00520-021-06316-4
M3 - Journal article
C2 - 34080053
AN - SCOPUS:85107428580
VL - 29
SP - 7431
EP - 7439
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
SN - 0941-4355
ER -
ID: 272500101