Synergistic permeability enhancing effect of lysophospholipids and fatty acids on lipid membranes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Synergistic permeability enhancing effect of lysophospholipids and fatty acids on lipid membranes. / Davidsen, Jesper; Mouritsen, Ole G.; Jorgensen, Kent.

In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1564, No. 1, 19.08.2002, p. 256-262.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Davidsen, J, Mouritsen, OG & Jorgensen, K 2002, 'Synergistic permeability enhancing effect of lysophospholipids and fatty acids on lipid membranes', Biochimica et Biophysica Acta - Biomembranes, vol. 1564, no. 1, pp. 256-262. https://doi.org/10.1016/S0005-2736(02)00461-3

APA

Davidsen, J., Mouritsen, O. G., & Jorgensen, K. (2002). Synergistic permeability enhancing effect of lysophospholipids and fatty acids on lipid membranes. Biochimica et Biophysica Acta - Biomembranes, 1564(1), 256-262. https://doi.org/10.1016/S0005-2736(02)00461-3

Vancouver

Davidsen J, Mouritsen OG, Jorgensen K. Synergistic permeability enhancing effect of lysophospholipids and fatty acids on lipid membranes. Biochimica et Biophysica Acta - Biomembranes. 2002 Aug 19;1564(1):256-262. https://doi.org/10.1016/S0005-2736(02)00461-3

Author

Davidsen, Jesper ; Mouritsen, Ole G. ; Jorgensen, Kent. / Synergistic permeability enhancing effect of lysophospholipids and fatty acids on lipid membranes. In: Biochimica et Biophysica Acta - Biomembranes. 2002 ; Vol. 1564, No. 1. pp. 256-262.

Bibtex

@article{769144008f2a424ca6a216af2351cce2,
title = "Synergistic permeability enhancing effect of lysophospholipids and fatty acids on lipid membranes",
abstract = "The permeability-enhancing effects of the two surfactants, 1-palmitoyl-2-lyso-sn-gycero-3-phosphocholine (lysoPPC) and palmitic acid (PA), on lipid membranes that at physiological temperatures are in the gel, fluid, and liquid-ordered phases were determined using the concentration-dependent self-quenching properties of the hydrophilic marker, calcein. Adding lysoPPC to lipid membranes in the gel-phase induced a time-dependent calcein release curve that can be described by the sum of two exponentials, whereas PA induces a considerably more complex release curve. However, when lysoPPC and PA were added simultaneously in equimolar concentrations, a dramatic synergistic permeability-enhancing effect was observed. In contrast, when both lysoPPC and PA are added to liposomal membranes that are in the fluid or liquid-ordered phases, no effect on the transmembrane permeation of calcein was observed.",
keywords = "Drug-delivery, Enhancer, Fatty acid, Liposome, Lysophospholipid, Membrane, Permeability, Surfactant",
author = "Jesper Davidsen and Mouritsen, {Ole G.} and Kent Jorgensen",
year = "2002",
month = aug,
day = "19",
doi = "10.1016/S0005-2736(02)00461-3",
language = "English",
volume = "1564",
pages = "256--262",
journal = "B B A - Biomembranes",
issn = "0005-2736",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Synergistic permeability enhancing effect of lysophospholipids and fatty acids on lipid membranes

AU - Davidsen, Jesper

AU - Mouritsen, Ole G.

AU - Jorgensen, Kent

PY - 2002/8/19

Y1 - 2002/8/19

N2 - The permeability-enhancing effects of the two surfactants, 1-palmitoyl-2-lyso-sn-gycero-3-phosphocholine (lysoPPC) and palmitic acid (PA), on lipid membranes that at physiological temperatures are in the gel, fluid, and liquid-ordered phases were determined using the concentration-dependent self-quenching properties of the hydrophilic marker, calcein. Adding lysoPPC to lipid membranes in the gel-phase induced a time-dependent calcein release curve that can be described by the sum of two exponentials, whereas PA induces a considerably more complex release curve. However, when lysoPPC and PA were added simultaneously in equimolar concentrations, a dramatic synergistic permeability-enhancing effect was observed. In contrast, when both lysoPPC and PA are added to liposomal membranes that are in the fluid or liquid-ordered phases, no effect on the transmembrane permeation of calcein was observed.

AB - The permeability-enhancing effects of the two surfactants, 1-palmitoyl-2-lyso-sn-gycero-3-phosphocholine (lysoPPC) and palmitic acid (PA), on lipid membranes that at physiological temperatures are in the gel, fluid, and liquid-ordered phases were determined using the concentration-dependent self-quenching properties of the hydrophilic marker, calcein. Adding lysoPPC to lipid membranes in the gel-phase induced a time-dependent calcein release curve that can be described by the sum of two exponentials, whereas PA induces a considerably more complex release curve. However, when lysoPPC and PA were added simultaneously in equimolar concentrations, a dramatic synergistic permeability-enhancing effect was observed. In contrast, when both lysoPPC and PA are added to liposomal membranes that are in the fluid or liquid-ordered phases, no effect on the transmembrane permeation of calcein was observed.

KW - Drug-delivery

KW - Enhancer

KW - Fatty acid

KW - Liposome

KW - Lysophospholipid

KW - Membrane

KW - Permeability

KW - Surfactant

UR - http://www.scopus.com/inward/record.url?scp=0037136068&partnerID=8YFLogxK

U2 - 10.1016/S0005-2736(02)00461-3

DO - 10.1016/S0005-2736(02)00461-3

M3 - Journal article

C2 - 12101020

AN - SCOPUS:0037136068

VL - 1564

SP - 256

EP - 262

JO - B B A - Biomembranes

JF - B B A - Biomembranes

SN - 0005-2736

IS - 1

ER -

ID: 230987051