Synbiotic Lactobacillus acidophilus NCFM and cellobiose does not affect human gut bacterial diversity but increases abundance of lactobacilli, bifidobacteria and branched-chain fatty acids: a randomized, double-blinded cross-over trial

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Synbiotic Lactobacillus acidophilus NCFM and cellobiose does not affect human gut bacterial diversity but increases abundance of lactobacilli, bifidobacteria and branched-chain fatty acids : a randomized, double-blinded cross-over trial. / van Zanten, Gabriella Christina; Krych, Lukasz; Röytiö, Henna; Forssten, Sofia; Lahtinen, Sampo J.; Abu Al-Soud, Waleed; Sørensen, Søren Johannes; Svensson, Birte; Jespersen, Lene; Jakobsen, Mogens.

In: F E M S Microbiology Ecology, Vol. 90, No. 1, 2014, p. 225-236.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

van Zanten, GC, Krych, L, Röytiö, H, Forssten, S, Lahtinen, SJ, Abu Al-Soud, W, Sørensen, SJ, Svensson, B, Jespersen, L & Jakobsen, M 2014, 'Synbiotic Lactobacillus acidophilus NCFM and cellobiose does not affect human gut bacterial diversity but increases abundance of lactobacilli, bifidobacteria and branched-chain fatty acids: a randomized, double-blinded cross-over trial', F E M S Microbiology Ecology, vol. 90, no. 1, pp. 225-236. https://doi.org/10.1111/1574-6941.12397

APA

van Zanten, G. C., Krych, L., Röytiö, H., Forssten, S., Lahtinen, S. J., Abu Al-Soud, W., ... Jakobsen, M. (2014). Synbiotic Lactobacillus acidophilus NCFM and cellobiose does not affect human gut bacterial diversity but increases abundance of lactobacilli, bifidobacteria and branched-chain fatty acids: a randomized, double-blinded cross-over trial. F E M S Microbiology Ecology, 90(1), 225-236. https://doi.org/10.1111/1574-6941.12397

Vancouver

van Zanten GC, Krych L, Röytiö H, Forssten S, Lahtinen SJ, Abu Al-Soud W et al. Synbiotic Lactobacillus acidophilus NCFM and cellobiose does not affect human gut bacterial diversity but increases abundance of lactobacilli, bifidobacteria and branched-chain fatty acids: a randomized, double-blinded cross-over trial. F E M S Microbiology Ecology. 2014;90(1):225-236. https://doi.org/10.1111/1574-6941.12397

Author

van Zanten, Gabriella Christina ; Krych, Lukasz ; Röytiö, Henna ; Forssten, Sofia ; Lahtinen, Sampo J. ; Abu Al-Soud, Waleed ; Sørensen, Søren Johannes ; Svensson, Birte ; Jespersen, Lene ; Jakobsen, Mogens. / Synbiotic Lactobacillus acidophilus NCFM and cellobiose does not affect human gut bacterial diversity but increases abundance of lactobacilli, bifidobacteria and branched-chain fatty acids : a randomized, double-blinded cross-over trial. In: F E M S Microbiology Ecology. 2014 ; Vol. 90, No. 1. pp. 225-236.

Bibtex

@article{e5d43538ca9b4511b8a2e89a0bcf4d4e,
title = "Synbiotic Lactobacillus acidophilus NCFM and cellobiose does not affect human gut bacterial diversity but increases abundance of lactobacilli, bifidobacteria and branched-chain fatty acids: a randomized, double-blinded cross-over trial",
abstract = "Probiotics, prebiotics and combinations thereof, i.e. synbiotics, have been reported to modulate gut microbiota of humans. In the present study effects of a novel synbiotic on the composition and metabolic activity of human gut microbiota were investigated. Healthy volunteers (n =18) were enrolled in a double-blinded, randomized, placebo-controlled crossover study and received synbiotic (Lactobacillus acidophilus NCFM (10(9) CFU) and cellobiose (5g)) or placebo daily for three weeks. Fecal samples were collected and lactobacilli numbers were quantified by qPCR. Furthermore, 454 tag encoded amplicon pyrosequencing was used to monitor the effect of synbiotic on the composition of the microbiota. The synbiotic increased levels of Lactobacillus spp. and relative abundances of the genera Bifidobacterium, Collinsella and Eubacterium while the genus Dialister was decreased (p < 0.05). No other effects were found on microbiota composition. Remarkably, however the synbiotic increased concentrations of branched-chain fatty acids, measured by gas chromatography, while short-chain fatty acids were not affected. This article is protected by copyright. All rights reserved.",
author = "{van Zanten}, {Gabriella Christina} and Lukasz Krych and Henna R{\"o}yti{\"o} and Sofia Forssten and Lahtinen, {Sampo J.} and {Abu Al-Soud}, Waleed and S{\o}rensen, {S{\o}ren Johannes} and Birte Svensson and Lene Jespersen and Mogens Jakobsen",
note = "This article is protected by copyright. All rights reserved.",
year = "2014",
doi = "10.1111/1574-6941.12397",
language = "English",
volume = "90",
pages = "225--236",
journal = "F E M S Microbiology Ecology",
issn = "0168-6496",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Synbiotic Lactobacillus acidophilus NCFM and cellobiose does not affect human gut bacterial diversity but increases abundance of lactobacilli, bifidobacteria and branched-chain fatty acids

T2 - a randomized, double-blinded cross-over trial

AU - van Zanten, Gabriella Christina

AU - Krych, Lukasz

AU - Röytiö, Henna

AU - Forssten, Sofia

AU - Lahtinen, Sampo J.

AU - Abu Al-Soud, Waleed

AU - Sørensen, Søren Johannes

AU - Svensson, Birte

AU - Jespersen, Lene

AU - Jakobsen, Mogens

N1 - This article is protected by copyright. All rights reserved.

PY - 2014

Y1 - 2014

N2 - Probiotics, prebiotics and combinations thereof, i.e. synbiotics, have been reported to modulate gut microbiota of humans. In the present study effects of a novel synbiotic on the composition and metabolic activity of human gut microbiota were investigated. Healthy volunteers (n =18) were enrolled in a double-blinded, randomized, placebo-controlled crossover study and received synbiotic (Lactobacillus acidophilus NCFM (10(9) CFU) and cellobiose (5g)) or placebo daily for three weeks. Fecal samples were collected and lactobacilli numbers were quantified by qPCR. Furthermore, 454 tag encoded amplicon pyrosequencing was used to monitor the effect of synbiotic on the composition of the microbiota. The synbiotic increased levels of Lactobacillus spp. and relative abundances of the genera Bifidobacterium, Collinsella and Eubacterium while the genus Dialister was decreased (p < 0.05). No other effects were found on microbiota composition. Remarkably, however the synbiotic increased concentrations of branched-chain fatty acids, measured by gas chromatography, while short-chain fatty acids were not affected. This article is protected by copyright. All rights reserved.

AB - Probiotics, prebiotics and combinations thereof, i.e. synbiotics, have been reported to modulate gut microbiota of humans. In the present study effects of a novel synbiotic on the composition and metabolic activity of human gut microbiota were investigated. Healthy volunteers (n =18) were enrolled in a double-blinded, randomized, placebo-controlled crossover study and received synbiotic (Lactobacillus acidophilus NCFM (10(9) CFU) and cellobiose (5g)) or placebo daily for three weeks. Fecal samples were collected and lactobacilli numbers were quantified by qPCR. Furthermore, 454 tag encoded amplicon pyrosequencing was used to monitor the effect of synbiotic on the composition of the microbiota. The synbiotic increased levels of Lactobacillus spp. and relative abundances of the genera Bifidobacterium, Collinsella and Eubacterium while the genus Dialister was decreased (p < 0.05). No other effects were found on microbiota composition. Remarkably, however the synbiotic increased concentrations of branched-chain fatty acids, measured by gas chromatography, while short-chain fatty acids were not affected. This article is protected by copyright. All rights reserved.

U2 - 10.1111/1574-6941.12397

DO - 10.1111/1574-6941.12397

M3 - Journal article

VL - 90

SP - 225

EP - 236

JO - F E M S Microbiology Ecology

JF - F E M S Microbiology Ecology

SN - 0168-6496

IS - 1

ER -

ID: 120837669