Structural properties and protective effect of Sargassum fusiforme polysaccharides against ultraviolet B radiation in hairless Kun Ming mice
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Structural properties and protective effect of Sargassum fusiforme polysaccharides against ultraviolet B radiation in hairless Kun Ming mice. / Ye, Yuhui; Ji, Desheng; You, Lijun; Zhou, Lin; Zhao, Zhengang; Brennan, Charles.
In: Journal of Functional Foods, Vol. 43, 2018, p. 8-16.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Structural properties and protective effect of Sargassum fusiforme polysaccharides against ultraviolet B radiation in hairless Kun Ming mice
AU - Ye, Yuhui
AU - Ji, Desheng
AU - You, Lijun
AU - Zhou, Lin
AU - Zhao, Zhengang
AU - Brennan, Charles
PY - 2018
Y1 - 2018
N2 - Sargassum fusiforme polysaccharide (SFP) was extracted from Sargassum fusiforme by hot water boiling, concentration and ethanol precipitation. The composition was determined as 58.10 ± 2.12% carbohydrate, 1.01 ± 0.15% protein, 9.85 ± 0.96% sulfate group and 17.66 ± 0.54% glucuronic acid. The average molecular weight of SFP was 224 kDa. The monosaccharide composition of SFP was 43.2% L-fucose, 3.5% rhamnose, 18.4% galactose, 1.5% glucose, 18.5% fructose, 5.9% xylose and 9.0% mannose respectively. SFP showed significant protective effect against ultraviolet B (UVB) radiation in hairless Kun Ming (KM) mice by manipulating the skin water content and thymus and spleen indexes. SFP could also alleviate UVB-induced oxidative stress by enhancing the activities of superoxide dismutase (SOD) and catalase (CAT) and reducing the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) equivalents. The levels of matrix metalloproteinase (MMP)-1 and 9 were also suppressed in SFP treatments. These findings suggest that SFP could be used as a potential functional food supplement for skin protection.
AB - Sargassum fusiforme polysaccharide (SFP) was extracted from Sargassum fusiforme by hot water boiling, concentration and ethanol precipitation. The composition was determined as 58.10 ± 2.12% carbohydrate, 1.01 ± 0.15% protein, 9.85 ± 0.96% sulfate group and 17.66 ± 0.54% glucuronic acid. The average molecular weight of SFP was 224 kDa. The monosaccharide composition of SFP was 43.2% L-fucose, 3.5% rhamnose, 18.4% galactose, 1.5% glucose, 18.5% fructose, 5.9% xylose and 9.0% mannose respectively. SFP showed significant protective effect against ultraviolet B (UVB) radiation in hairless Kun Ming (KM) mice by manipulating the skin water content and thymus and spleen indexes. SFP could also alleviate UVB-induced oxidative stress by enhancing the activities of superoxide dismutase (SOD) and catalase (CAT) and reducing the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) equivalents. The levels of matrix metalloproteinase (MMP)-1 and 9 were also suppressed in SFP treatments. These findings suggest that SFP could be used as a potential functional food supplement for skin protection.
KW - Oxidative stress
KW - Polysaccharides
KW - Sargassum fusiforme
KW - Skin protection
KW - Ultraviolet B
U2 - 10.1016/j.jff.2018.01.025
DO - 10.1016/j.jff.2018.01.025
M3 - Journal article
AN - SCOPUS:85041601799
VL - 43
SP - 8
EP - 16
JO - Journal of Functional Foods
JF - Journal of Functional Foods
SN - 1756-4646
ER -
ID: 208721939