Role of lipid protrusions in the function of interfacial enzymes

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Secretory phospholipase A2 (sPLA2) is a class of interfacially active enzymes that selectively hydrolyze lipid molecules organized at interfaces like membranes. We present a simple theoretical model that relates the sPLA2 action to the protrusions of the lipid molecules. The model explains (1) the observed enhancement of enzymatic activity by lipids with flexible, neutral, water-soluble polymers linked to their head groups and (2) the lag-burst kinetics of sPLA2. It yields qualitative predictions of the effect of the initial composition of the membrane, the molecular weight of the polymer, and the composition of the hydrolysis products.

Original languageEnglish
JournalEuropean Biophysics Journal
Issue number7
Pages (from-to)967-971
Number of pages5
Publication statusPublished - 1 Oct 2005

ID: 230985105