Role of lipid protrusions in the function of interfacial enzymes
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Role of lipid protrusions in the function of interfacial enzymes. / Halperin, Avi; Mouritsen, Ole G.
In: European Biophysics Journal, Vol. 34, No. 7, 01.10.2005, p. 967-971.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Role of lipid protrusions in the function of interfacial enzymes
AU - Halperin, Avi
AU - Mouritsen, Ole G.
PY - 2005/10/1
Y1 - 2005/10/1
N2 - Secretory phospholipase A2 (sPLA2) is a class of interfacially active enzymes that selectively hydrolyze lipid molecules organized at interfaces like membranes. We present a simple theoretical model that relates the sPLA2 action to the protrusions of the lipid molecules. The model explains (1) the observed enhancement of enzymatic activity by lipids with flexible, neutral, water-soluble polymers linked to their head groups and (2) the lag-burst kinetics of sPLA2. It yields qualitative predictions of the effect of the initial composition of the membrane, the molecular weight of the polymer, and the composition of the hydrolysis products.
AB - Secretory phospholipase A2 (sPLA2) is a class of interfacially active enzymes that selectively hydrolyze lipid molecules organized at interfaces like membranes. We present a simple theoretical model that relates the sPLA2 action to the protrusions of the lipid molecules. The model explains (1) the observed enhancement of enzymatic activity by lipids with flexible, neutral, water-soluble polymers linked to their head groups and (2) the lag-burst kinetics of sPLA2. It yields qualitative predictions of the effect of the initial composition of the membrane, the molecular weight of the polymer, and the composition of the hydrolysis products.
UR - http://www.scopus.com/inward/record.url?scp=26444578399&partnerID=8YFLogxK
U2 - 10.1007/s00249-005-0466-z
DO - 10.1007/s00249-005-0466-z
M3 - Journal article
C2 - 15883844
AN - SCOPUS:26444578399
VL - 34
SP - 967
EP - 971
JO - European Biophysics Journal
JF - European Biophysics Journal
SN - 0175-7571
IS - 7
ER -
ID: 230985105