Phase equilibria and local structure in binary lipid bilayers
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Phase equilibria and local structure in binary lipid bilayers. / Jørgensen, Kent; Sperotto, Maria Maddalena; Mouritsen, Ole G.; Ipsen, John Hjort; Zuckermann, Martin J.
In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1152, No. 1, 1993, p. 135-145.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Phase equilibria and local structure in binary lipid bilayers
AU - Jørgensen, Kent
AU - Sperotto, Maria Maddalena
AU - Mouritsen, Ole G.
AU - Ipsen, John Hjort
AU - Zuckermann, Martin J.
PY - 1993
Y1 - 1993
N2 - A molecular interaction model is used to describe the phase diagram of two-component phospholipid bilayer membranes of saturated phospholipids, DCnPC, with different acyl-chain lengths, n = 12,14,18,20. The interaction between acyl chains of different length is formulated in terms of a hydrophobic mismatch which permits the series of binary phase diagrams to be calculated in terms of a single 'universal' interaction parameter. The properties of the model are calculated by computer-simulation techniques which not only permit determination of the specific-heat function and the phase diagram but also reveal the local structure of the mixture in the different parts of the phase diagram. The local structure is described pictorially and characterized quantitatively in terms of a correlation function. It is shown that the non-ideal mixing of lipid species due to mismatch in the hydrophobic lengths leads to a progressively increasing local ordering as the chain-length difference is increased. A pronounced local structure is found to persist deep inside the fluid phase of the mixture. The local structure is discussed in relation to the features observed in the specific-heat function, for which theoretical data, as well as experimental data obtained from differential-scanning calorimetry are presented.
AB - A molecular interaction model is used to describe the phase diagram of two-component phospholipid bilayer membranes of saturated phospholipids, DCnPC, with different acyl-chain lengths, n = 12,14,18,20. The interaction between acyl chains of different length is formulated in terms of a hydrophobic mismatch which permits the series of binary phase diagrams to be calculated in terms of a single 'universal' interaction parameter. The properties of the model are calculated by computer-simulation techniques which not only permit determination of the specific-heat function and the phase diagram but also reveal the local structure of the mixture in the different parts of the phase diagram. The local structure is described pictorially and characterized quantitatively in terms of a correlation function. It is shown that the non-ideal mixing of lipid species due to mismatch in the hydrophobic lengths leads to a progressively increasing local ordering as the chain-length difference is increased. A pronounced local structure is found to persist deep inside the fluid phase of the mixture. The local structure is discussed in relation to the features observed in the specific-heat function, for which theoretical data, as well as experimental data obtained from differential-scanning calorimetry are presented.
KW - Binary lipid bilayer
KW - Correlation function
KW - Local structure
KW - Phase diagram
KW - Specific heat
U2 - 10.1016/0005-2736(93)90240-Z
DO - 10.1016/0005-2736(93)90240-Z
M3 - Journal article
C2 - 8399291
AN - SCOPUS:0027374780
VL - 1152
SP - 135
EP - 145
JO - B B A - Biomembranes
JF - B B A - Biomembranes
SN - 0005-2736
IS - 1
ER -
ID: 236891339