Morphology and Structure of Solid Lipid Nanoparticles Loaded with High Concentrations of β-Carotene
Research output: Contribution to journal › Journal article › peer-review
Standard
Morphology and Structure of Solid Lipid Nanoparticles Loaded with High Concentrations of β-Carotene. / Schjoerring-Thyssen, Jakob; Olsen, Karsten; Koehler, Klaus; Jouenne, Eric; Rousseau, Dérick; Andersen, Mogens Larsen.
In: Journal of Agricultural and Food Chemistry, Vol. 67, No. 44, 2019, p. 12273-12282.Research output: Contribution to journal › Journal article › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Morphology and Structure of Solid Lipid Nanoparticles Loaded with High Concentrations of β-Carotene
AU - Schjoerring-Thyssen, Jakob
AU - Olsen, Karsten
AU - Koehler, Klaus
AU - Jouenne, Eric
AU - Rousseau, Dérick
AU - Andersen, Mogens Larsen
PY - 2019
Y1 - 2019
N2 - Solid lipid nanoparticles (SLNs) containing up to 37.5 wt % all-trans β-carotene in the lipid phase are potential water-dispersible food colorants. SLNs have been made by hot-melt high-pressure homogenization with fully hydrogenated sunflower oil and with polysorbate 80 and sunflower lecithin as stabilizers. Atomic force microscopy revealed the SLNs had thin platelet structures most likely derived from the triglyceride crystal β-form, as detected by X-ray diffraction. No indications of crystalline β-carotene were detected. High-performance liquid chromatography analysis showed the extensive isomerization of β-carotene into more than 10 cis isomers, suggesting that it is present as an amorphous mixture. The high β-carotene loadings did not affect the triglyceride crystal structure and the morphology of the SLNs. It is suggested the SLNs consist of a platelet core of crystalline triglyceride surrounded by an amorphous β-carotene-containing layer. The layered structure is suggested to affect the coloring power of the SLNs at β-carotene loadings above 15 wt % of the lipid phase.
AB - Solid lipid nanoparticles (SLNs) containing up to 37.5 wt % all-trans β-carotene in the lipid phase are potential water-dispersible food colorants. SLNs have been made by hot-melt high-pressure homogenization with fully hydrogenated sunflower oil and with polysorbate 80 and sunflower lecithin as stabilizers. Atomic force microscopy revealed the SLNs had thin platelet structures most likely derived from the triglyceride crystal β-form, as detected by X-ray diffraction. No indications of crystalline β-carotene were detected. High-performance liquid chromatography analysis showed the extensive isomerization of β-carotene into more than 10 cis isomers, suggesting that it is present as an amorphous mixture. The high β-carotene loadings did not affect the triglyceride crystal structure and the morphology of the SLNs. It is suggested the SLNs consist of a platelet core of crystalline triglyceride surrounded by an amorphous β-carotene-containing layer. The layered structure is suggested to affect the coloring power of the SLNs at β-carotene loadings above 15 wt % of the lipid phase.
KW - AFM
KW - food color
KW - SLN
KW - X-ray diffraction
KW - β-carotene
U2 - 10.1021/acs.jafc.9b04215
DO - 10.1021/acs.jafc.9b04215
M3 - Journal article
C2 - 31610122
AN - SCOPUS:85074224882
VL - 67
SP - 12273
EP - 12282
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
SN - 0021-8561
IS - 44
ER -
ID: 230896700