Model of a sub-main transition in phospholipid bilayers

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  • Morten Nielsen
  • Ling Miao
  • John H. Ipsen
  • Kent Jørgensen
  • Martin J. Zuckermann
  • Ole G. Mouritsen

A recently discovered submain phase transition in multi-lamellar bilayers of long-chain saturated diacyl phosphatidylcholines (Jorgensen, K. (1995) Biochim. Biophys. Acta 1240, 111-114) is discussed in terms of a theoretical molecular interaction model using computer simulation techniques. The model interprets the transition to be due to a decoupling of the acyl-chain melting from the melting of the pseudo-two-dimensional crystalline lattice of the P(β') phase. A two-stage melting process is predicted by the calculations suggesting that the sub-main transition involves a lattice melting whereas the acyl-chain melting takes place at a higher temperature at the main transition. The calculated heat contents of the two transitions as well as the chain-length dependence compare favorably with experimental data for multi-lamellar phosphatidylcholine lipid bilayers.

Original languageEnglish
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1283
Issue number2
Pages (from-to)170-176
Number of pages7
ISSN0005-2736
DOIs
Publication statusPublished - 4 Sep 1996

    Research areas

  • Calorimetry, Chain melting, Lattice melting, Lipid bilayer, Phospholipid, Submain phase transition, Theoretical model

ID: 236887743