Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain : single and multiple dosing studies. / Folkesson, Anna; Honoré, Per Hartvig; Andersen, Lene Munkholm; Kristensen, Pernille Juul; Bjerrum, Ole Jannik.

In: Journal of Neural Transmission, Vol. 117, 2010, p. 1377-1385.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Folkesson, A, Honoré, PH, Andersen, LM, Kristensen, PJ & Bjerrum, OJ 2010, 'Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies', Journal of Neural Transmission, vol. 117, pp. 1377-1385. https://doi.org/10.1007/s00702-010-0494-4

APA

Folkesson, A., Honoré, P. H., Andersen, L. M., Kristensen, P. J., & Bjerrum, O. J. (2010). Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies. Journal of Neural Transmission, 117, 1377-1385. https://doi.org/10.1007/s00702-010-0494-4

Vancouver

Folkesson A, Honoré PH, Andersen LM, Kristensen PJ, Bjerrum OJ. Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies. Journal of Neural Transmission. 2010;117:1377-1385. https://doi.org/10.1007/s00702-010-0494-4

Author

Folkesson, Anna ; Honoré, Per Hartvig ; Andersen, Lene Munkholm ; Kristensen, Pernille Juul ; Bjerrum, Ole Jannik. / Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain : single and multiple dosing studies. In: Journal of Neural Transmission. 2010 ; Vol. 117. pp. 1377-1385.

Bibtex

@article{2140ec633be44940a60f2c28e5ae179c,
title = "Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies",
abstract = "The use of cholinergic drugs, either alone or in combination with other drugs, has been suggested as an approach to improve treatment outcome for patients suffering from neuropathic pain. The present study was undertaken in the rat spared nerve injury model of neuropathic pain to evaluate the effect of the cholinesterase inhibitor donepezil when administered (1) alone and (2) as low-dose in combination with the first-line recommendation gabapentin. The co-administration studies were performed following single and multiple dosing. Single, parenteral dosing of donepezil (1, 1.5 and 3 mg/kg s.c.) produced a dose-dependent reversal of the neuropathic pain behaviour. Co-administration of a sub-effective dose of donepezil (0.5 mg/kg s.c.) and low doses of gabapentin (10 and 30 mg/kg s.c.) resulted in a three- to fourfold increase of the analgesic effect, in comparison with gabapentin administered alone. Following multiple, oral dosing, gabapentin (25 mg/kg p.o.) was administered once daily over 20 days. Addition of donepezil (1.5 mg/kg p.o.) from day 11 to day 20 resulted in improved analgesia during the period of combination therapy, in comparison with the gabapentin monotherapy period. Furthermore, the treatment effects were stable in both the mono- and the combination therapy period, indicating that tolerance development does not occur within the studied time frame. In conclusion, the results from this preclinical study support the use of donepezil as adjunctive to gabapentin to improve the therapeutic outcome in the management of neuropathic pain.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Anna Folkesson and Honor{\'e}, {Per Hartvig} and Andersen, {Lene Munkholm} and Kristensen, {Pernille Juul} and Bjerrum, {Ole Jannik}",
note = "Published online: 02 october 2010",
year = "2010",
doi = "10.1007/s00702-010-0494-4",
language = "English",
volume = "117",
pages = "1377--1385",
journal = "Journal of Neural Transmission",
issn = "0300-9564",
publisher = "Springer Wien",

}

RIS

TY - JOUR

T1 - Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain

T2 - single and multiple dosing studies

AU - Folkesson, Anna

AU - Honoré, Per Hartvig

AU - Andersen, Lene Munkholm

AU - Kristensen, Pernille Juul

AU - Bjerrum, Ole Jannik

N1 - Published online: 02 october 2010

PY - 2010

Y1 - 2010

N2 - The use of cholinergic drugs, either alone or in combination with other drugs, has been suggested as an approach to improve treatment outcome for patients suffering from neuropathic pain. The present study was undertaken in the rat spared nerve injury model of neuropathic pain to evaluate the effect of the cholinesterase inhibitor donepezil when administered (1) alone and (2) as low-dose in combination with the first-line recommendation gabapentin. The co-administration studies were performed following single and multiple dosing. Single, parenteral dosing of donepezil (1, 1.5 and 3 mg/kg s.c.) produced a dose-dependent reversal of the neuropathic pain behaviour. Co-administration of a sub-effective dose of donepezil (0.5 mg/kg s.c.) and low doses of gabapentin (10 and 30 mg/kg s.c.) resulted in a three- to fourfold increase of the analgesic effect, in comparison with gabapentin administered alone. Following multiple, oral dosing, gabapentin (25 mg/kg p.o.) was administered once daily over 20 days. Addition of donepezil (1.5 mg/kg p.o.) from day 11 to day 20 resulted in improved analgesia during the period of combination therapy, in comparison with the gabapentin monotherapy period. Furthermore, the treatment effects were stable in both the mono- and the combination therapy period, indicating that tolerance development does not occur within the studied time frame. In conclusion, the results from this preclinical study support the use of donepezil as adjunctive to gabapentin to improve the therapeutic outcome in the management of neuropathic pain.

AB - The use of cholinergic drugs, either alone or in combination with other drugs, has been suggested as an approach to improve treatment outcome for patients suffering from neuropathic pain. The present study was undertaken in the rat spared nerve injury model of neuropathic pain to evaluate the effect of the cholinesterase inhibitor donepezil when administered (1) alone and (2) as low-dose in combination with the first-line recommendation gabapentin. The co-administration studies were performed following single and multiple dosing. Single, parenteral dosing of donepezil (1, 1.5 and 3 mg/kg s.c.) produced a dose-dependent reversal of the neuropathic pain behaviour. Co-administration of a sub-effective dose of donepezil (0.5 mg/kg s.c.) and low doses of gabapentin (10 and 30 mg/kg s.c.) resulted in a three- to fourfold increase of the analgesic effect, in comparison with gabapentin administered alone. Following multiple, oral dosing, gabapentin (25 mg/kg p.o.) was administered once daily over 20 days. Addition of donepezil (1.5 mg/kg p.o.) from day 11 to day 20 resulted in improved analgesia during the period of combination therapy, in comparison with the gabapentin monotherapy period. Furthermore, the treatment effects were stable in both the mono- and the combination therapy period, indicating that tolerance development does not occur within the studied time frame. In conclusion, the results from this preclinical study support the use of donepezil as adjunctive to gabapentin to improve the therapeutic outcome in the management of neuropathic pain.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1007/s00702-010-0494-4

DO - 10.1007/s00702-010-0494-4

M3 - Journal article

C2 - 20890617

VL - 117

SP - 1377

EP - 1385

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

SN - 0300-9564

ER -

ID: 32085914