Lipases, liposomes and lipid-prodrugs

Research output: Contribution to journalReviewpeer-review

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Lipases, liposomes and lipid-prodrugs. / Arouri, Ahmad; Hansen, Anders Højgaard; Rasmussen, Thomas Elmelund; Mouritsen, Ole G.

In: Current Opinion in Colloid and Interface Science, Vol. 18, No. 5, 2013, p. 419-431.

Research output: Contribution to journalReviewpeer-review

Harvard

Arouri, A, Hansen, AH, Rasmussen, TE & Mouritsen, OG 2013, 'Lipases, liposomes and lipid-prodrugs', Current Opinion in Colloid and Interface Science, vol. 18, no. 5, pp. 419-431. https://doi.org/10.1016/j.cocis.2013.06.001

APA

Arouri, A., Hansen, A. H., Rasmussen, T. E., & Mouritsen, O. G. (2013). Lipases, liposomes and lipid-prodrugs. Current Opinion in Colloid and Interface Science, 18(5), 419-431. https://doi.org/10.1016/j.cocis.2013.06.001

Vancouver

Arouri A, Hansen AH, Rasmussen TE, Mouritsen OG. Lipases, liposomes and lipid-prodrugs. Current Opinion in Colloid and Interface Science. 2013;18(5):419-431. https://doi.org/10.1016/j.cocis.2013.06.001

Author

Arouri, Ahmad ; Hansen, Anders Højgaard ; Rasmussen, Thomas Elmelund ; Mouritsen, Ole G. / Lipases, liposomes and lipid-prodrugs. In: Current Opinion in Colloid and Interface Science. 2013 ; Vol. 18, No. 5. pp. 419-431.

Bibtex

@article{1b1b5393de60417081f8619ac0096f2b,
title = "Lipases, liposomes and lipid-prodrugs",
abstract = "Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well as drug binding and action at diseased sites, e.g., in cancer therapy. We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs. Moreover these drugs can themselves be special lipid molecules in the form of lipid prodrugs that both form the liposomal carrier as well as the substrate for endogenously upregulated lipases that turn the prodrugs into potent drugs precisely at the diseased site.",
keywords = "Drug delivery, Interface, Liposome, Phospholipase, Prodrug",
author = "Ahmad Arouri and Hansen, {Anders H{\o}jgaard} and Rasmussen, {Thomas Elmelund} and Mouritsen, {Ole G.}",
year = "2013",
doi = "10.1016/j.cocis.2013.06.001",
language = "English",
volume = "18",
pages = "419--431",
journal = "Current Opinion in Colloid & Interface Science",
issn = "1359-0294",
publisher = "Pergamon Press",
number = "5",

}

RIS

TY - JOUR

T1 - Lipases, liposomes and lipid-prodrugs

AU - Arouri, Ahmad

AU - Hansen, Anders Højgaard

AU - Rasmussen, Thomas Elmelund

AU - Mouritsen, Ole G.

PY - 2013

Y1 - 2013

N2 - Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well as drug binding and action at diseased sites, e.g., in cancer therapy. We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs. Moreover these drugs can themselves be special lipid molecules in the form of lipid prodrugs that both form the liposomal carrier as well as the substrate for endogenously upregulated lipases that turn the prodrugs into potent drugs precisely at the diseased site.

AB - Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well as drug binding and action at diseased sites, e.g., in cancer therapy. We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs. Moreover these drugs can themselves be special lipid molecules in the form of lipid prodrugs that both form the liposomal carrier as well as the substrate for endogenously upregulated lipases that turn the prodrugs into potent drugs precisely at the diseased site.

KW - Drug delivery

KW - Interface

KW - Liposome

KW - Phospholipase

KW - Prodrug

U2 - 10.1016/j.cocis.2013.06.001

DO - 10.1016/j.cocis.2013.06.001

M3 - Review

AN - SCOPUS:84882264988

VL - 18

SP - 419

EP - 431

JO - Current Opinion in Colloid & Interface Science

JF - Current Opinion in Colloid & Interface Science

SN - 1359-0294

IS - 5

ER -

ID: 230974842