Lipases, liposomes and lipid-prodrugs
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Lipases, liposomes and lipid-prodrugs. / Arouri, Ahmad; Hansen, Anders Højgaard; Rasmussen, Thomas Elmelund; Mouritsen, Ole G.
In: Current Opinion in Colloid and Interface Science, Vol. 18, No. 5, 2013, p. 419-431.Research output: Contribution to journal › Review › peer-review
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TY - JOUR
T1 - Lipases, liposomes and lipid-prodrugs
AU - Arouri, Ahmad
AU - Hansen, Anders Højgaard
AU - Rasmussen, Thomas Elmelund
AU - Mouritsen, Ole G.
PY - 2013
Y1 - 2013
N2 - Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well as drug binding and action at diseased sites, e.g., in cancer therapy. We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs. Moreover these drugs can themselves be special lipid molecules in the form of lipid prodrugs that both form the liposomal carrier as well as the substrate for endogenously upregulated lipases that turn the prodrugs into potent drugs precisely at the diseased site.
AB - Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well as drug binding and action at diseased sites, e.g., in cancer therapy. We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs. Moreover these drugs can themselves be special lipid molecules in the form of lipid prodrugs that both form the liposomal carrier as well as the substrate for endogenously upregulated lipases that turn the prodrugs into potent drugs precisely at the diseased site.
KW - Drug delivery
KW - Interface
KW - Liposome
KW - Phospholipase
KW - Prodrug
U2 - 10.1016/j.cocis.2013.06.001
DO - 10.1016/j.cocis.2013.06.001
M3 - Review
AN - SCOPUS:84882264988
VL - 18
SP - 419
EP - 431
JO - Current Opinion in Colloid & Interface Science
JF - Current Opinion in Colloid & Interface Science
SN - 1359-0294
IS - 5
ER -
ID: 230974842