Lindane suppresses the lipid-bilayer permeability in the main transition region

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Lindane suppresses the lipid-bilayer permeability in the main transition region. / Sabra, Mads C.; Jørgensen, Kent; Mouritsen, Ole G.

In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1282, No. 1, 13.06.1996, p. 85-92.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sabra, MC, Jørgensen, K & Mouritsen, OG 1996, 'Lindane suppresses the lipid-bilayer permeability in the main transition region', Biochimica et Biophysica Acta - Biomembranes, vol. 1282, no. 1, pp. 85-92. https://doi.org/10.1016/0005-2736(96)00042-9

APA

Sabra, M. C., Jørgensen, K., & Mouritsen, O. G. (1996). Lindane suppresses the lipid-bilayer permeability in the main transition region. Biochimica et Biophysica Acta - Biomembranes, 1282(1), 85-92. https://doi.org/10.1016/0005-2736(96)00042-9

Vancouver

Sabra MC, Jørgensen K, Mouritsen OG. Lindane suppresses the lipid-bilayer permeability in the main transition region. Biochimica et Biophysica Acta - Biomembranes. 1996 Jun 13;1282(1):85-92. https://doi.org/10.1016/0005-2736(96)00042-9

Author

Sabra, Mads C. ; Jørgensen, Kent ; Mouritsen, Ole G. / Lindane suppresses the lipid-bilayer permeability in the main transition region. In: Biochimica et Biophysica Acta - Biomembranes. 1996 ; Vol. 1282, No. 1. pp. 85-92.

Bibtex

@article{05b75cad4f9044ae931731a39ca232d2,
title = "Lindane suppresses the lipid-bilayer permeability in the main transition region",
abstract = "The effects of a small molecule, the insecticide lindane, on unilamellar DMPC bilayers in the phase transition region, have been studied by means of differential scanning calorimetry and fluorescence spectroscopy. The calorimetric data show that increasing concentrations of lindane broaden the transition and lower the transition temperature, without changing the transition enthalpy significantly. Lindane therefore enhances the thermal fluctuations of the bilayer. The calorimetric data furthermore suggest that the bilayer structure is intact and not disrupted by even high concentrations (32 mol%) of lindane. Fluorescence spectroscopy was used to measure the passive permeability of unilamellar DMPC bilayers to Co2+ ions. The data show that lindane seals the bilayer for Co2+ penetration and that this effect increases with increasing lindane concentration. The results are discussed in relation to the effects on the permeability of other small molecules, e.g., anesthetics.",
keywords = "Fluorescence spectroscopy, Lindane, Lipid bilayer, Permeability, Phase transition",
author = "Sabra, {Mads C.} and Kent J{\o}rgensen and Mouritsen, {Ole G.}",
year = "1996",
month = jun,
day = "13",
doi = "10.1016/0005-2736(96)00042-9",
language = "English",
volume = "1282",
pages = "85--92",
journal = "B B A - Biomembranes",
issn = "0005-2736",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Lindane suppresses the lipid-bilayer permeability in the main transition region

AU - Sabra, Mads C.

AU - Jørgensen, Kent

AU - Mouritsen, Ole G.

PY - 1996/6/13

Y1 - 1996/6/13

N2 - The effects of a small molecule, the insecticide lindane, on unilamellar DMPC bilayers in the phase transition region, have been studied by means of differential scanning calorimetry and fluorescence spectroscopy. The calorimetric data show that increasing concentrations of lindane broaden the transition and lower the transition temperature, without changing the transition enthalpy significantly. Lindane therefore enhances the thermal fluctuations of the bilayer. The calorimetric data furthermore suggest that the bilayer structure is intact and not disrupted by even high concentrations (32 mol%) of lindane. Fluorescence spectroscopy was used to measure the passive permeability of unilamellar DMPC bilayers to Co2+ ions. The data show that lindane seals the bilayer for Co2+ penetration and that this effect increases with increasing lindane concentration. The results are discussed in relation to the effects on the permeability of other small molecules, e.g., anesthetics.

AB - The effects of a small molecule, the insecticide lindane, on unilamellar DMPC bilayers in the phase transition region, have been studied by means of differential scanning calorimetry and fluorescence spectroscopy. The calorimetric data show that increasing concentrations of lindane broaden the transition and lower the transition temperature, without changing the transition enthalpy significantly. Lindane therefore enhances the thermal fluctuations of the bilayer. The calorimetric data furthermore suggest that the bilayer structure is intact and not disrupted by even high concentrations (32 mol%) of lindane. Fluorescence spectroscopy was used to measure the passive permeability of unilamellar DMPC bilayers to Co2+ ions. The data show that lindane seals the bilayer for Co2+ penetration and that this effect increases with increasing lindane concentration. The results are discussed in relation to the effects on the permeability of other small molecules, e.g., anesthetics.

KW - Fluorescence spectroscopy

KW - Lindane

KW - Lipid bilayer

KW - Permeability

KW - Phase transition

UR - http://www.scopus.com/inward/record.url?scp=0029952264&partnerID=8YFLogxK

U2 - 10.1016/0005-2736(96)00042-9

DO - 10.1016/0005-2736(96)00042-9

M3 - Journal article

C2 - 8679664

AN - SCOPUS:0029952264

VL - 1282

SP - 85

EP - 92

JO - B B A - Biomembranes

JF - B B A - Biomembranes

SN - 0005-2736

IS - 1

ER -

ID: 236888097