Investigation of lipid membrane macro- and micro-structure using calorimetry and computer simulation: Structural and functional relationships

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Investigation of lipid membrane macro- and micro-structure using calorimetry and computer simulation : Structural and functional relationships. / Jørgensen, Kent; Mouritsen, Ole G.

In: Thermochimica Acta, Vol. 328, No. 1-2, 22.03.1999, p. 81-89.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jørgensen, K & Mouritsen, OG 1999, 'Investigation of lipid membrane macro- and micro-structure using calorimetry and computer simulation: Structural and functional relationships', Thermochimica Acta, vol. 328, no. 1-2, pp. 81-89.

APA

Jørgensen, K., & Mouritsen, O. G. (1999). Investigation of lipid membrane macro- and micro-structure using calorimetry and computer simulation: Structural and functional relationships. Thermochimica Acta, 328(1-2), 81-89.

Vancouver

Jørgensen K, Mouritsen OG. Investigation of lipid membrane macro- and micro-structure using calorimetry and computer simulation: Structural and functional relationships. Thermochimica Acta. 1999 Mar 22;328(1-2):81-89.

Author

Jørgensen, Kent ; Mouritsen, Ole G. / Investigation of lipid membrane macro- and micro-structure using calorimetry and computer simulation : Structural and functional relationships. In: Thermochimica Acta. 1999 ; Vol. 328, No. 1-2. pp. 81-89.

Bibtex

@article{c54ec15e83404db28327be20c074bb9c,
title = "Investigation of lipid membrane macro- and micro-structure using calorimetry and computer simulation: Structural and functional relationships",
abstract = "The lipid bilayer part of biological membranes is a complex lipid mixture displaying cooperative phenomena. By means of differential scanning calorimetry and computer simulation techniques, the equilibrium and non-equilibrium properties of the large assembly of mutually interacting amphiphilic lipid molecules constituting the lipid bilayer have been investigated. The cooperative many-particle lipid bilayer behavior is manifested in terms of phase transitions and large-scale macroscopic phase equilibria. On a smaller nanometer length-scale, equilibrium structural and compositional fluctuations lead to the formation of a heterogeneous lateral bilayer structure composed of dynamic lipid domains and differentiated bilayer regions. In addition, the non-equilibrium dynamic ordering process of coexisting phases can give rise to the formation of local lipid structures on various length- and time-scales. The results suggest that the structural and dynamical lipid bilayer behavior and in particular the appearance of small-scale lipid structures might be of importance for membrane functionality, e.g., membrane compartmentalization, trans-membrane permeability, and the activity of membrane-associated enzymes and proteins.",
keywords = "Differential scanning calorimetry, Lipid bilayer, Lipid domain, Membrane function, Micro-structure, Phase equilibria, Phase transition",
author = "Kent J{\o}rgensen and Mouritsen, {Ole G.}",
year = "1999",
month = mar,
day = "22",
language = "English",
volume = "328",
pages = "81--89",
journal = "Thermochimica Acta",
issn = "0040-6031",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Investigation of lipid membrane macro- and micro-structure using calorimetry and computer simulation

T2 - Structural and functional relationships

AU - Jørgensen, Kent

AU - Mouritsen, Ole G.

PY - 1999/3/22

Y1 - 1999/3/22

N2 - The lipid bilayer part of biological membranes is a complex lipid mixture displaying cooperative phenomena. By means of differential scanning calorimetry and computer simulation techniques, the equilibrium and non-equilibrium properties of the large assembly of mutually interacting amphiphilic lipid molecules constituting the lipid bilayer have been investigated. The cooperative many-particle lipid bilayer behavior is manifested in terms of phase transitions and large-scale macroscopic phase equilibria. On a smaller nanometer length-scale, equilibrium structural and compositional fluctuations lead to the formation of a heterogeneous lateral bilayer structure composed of dynamic lipid domains and differentiated bilayer regions. In addition, the non-equilibrium dynamic ordering process of coexisting phases can give rise to the formation of local lipid structures on various length- and time-scales. The results suggest that the structural and dynamical lipid bilayer behavior and in particular the appearance of small-scale lipid structures might be of importance for membrane functionality, e.g., membrane compartmentalization, trans-membrane permeability, and the activity of membrane-associated enzymes and proteins.

AB - The lipid bilayer part of biological membranes is a complex lipid mixture displaying cooperative phenomena. By means of differential scanning calorimetry and computer simulation techniques, the equilibrium and non-equilibrium properties of the large assembly of mutually interacting amphiphilic lipid molecules constituting the lipid bilayer have been investigated. The cooperative many-particle lipid bilayer behavior is manifested in terms of phase transitions and large-scale macroscopic phase equilibria. On a smaller nanometer length-scale, equilibrium structural and compositional fluctuations lead to the formation of a heterogeneous lateral bilayer structure composed of dynamic lipid domains and differentiated bilayer regions. In addition, the non-equilibrium dynamic ordering process of coexisting phases can give rise to the formation of local lipid structures on various length- and time-scales. The results suggest that the structural and dynamical lipid bilayer behavior and in particular the appearance of small-scale lipid structures might be of importance for membrane functionality, e.g., membrane compartmentalization, trans-membrane permeability, and the activity of membrane-associated enzymes and proteins.

KW - Differential scanning calorimetry

KW - Lipid bilayer

KW - Lipid domain

KW - Membrane function

KW - Micro-structure

KW - Phase equilibria

KW - Phase transition

UR - http://www.scopus.com/inward/record.url?scp=0007416092&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:0007416092

VL - 328

SP - 81

EP - 89

JO - Thermochimica Acta

JF - Thermochimica Acta

SN - 0040-6031

IS - 1-2

ER -

ID: 236895304