Expedited investigation of powder caking aided by rapid 3D prototyping of testing devices

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Expedited investigation of powder caking aided by rapid 3D prototyping of testing devices. / Hirschberg, Cosima; Boetker, Johan; Risbo, Jens; Sun, Changquan Calvin; Rantanen, Jukka.

In: Journal of Pharmaceutical Sciences, Vol. 109, No. 1, 2020, p. 769-774.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Hirschberg, C, Boetker, J, Risbo, J, Sun, CC & Rantanen, J 2020, 'Expedited investigation of powder caking aided by rapid 3D prototyping of testing devices', Journal of Pharmaceutical Sciences, vol. 109, no. 1, pp. 769-774. https://doi.org/10.1016/j.xphs.2019.07.022

APA

Hirschberg, C., Boetker, J., Risbo, J., Sun, C. C., & Rantanen, J. (2020). Expedited investigation of powder caking aided by rapid 3D prototyping of testing devices. Journal of Pharmaceutical Sciences, 109(1), 769-774. https://doi.org/10.1016/j.xphs.2019.07.022

Vancouver

Hirschberg C, Boetker J, Risbo J, Sun CC, Rantanen J. Expedited investigation of powder caking aided by rapid 3D prototyping of testing devices. Journal of Pharmaceutical Sciences. 2020;109(1):769-774. https://doi.org/10.1016/j.xphs.2019.07.022

Author

Hirschberg, Cosima ; Boetker, Johan ; Risbo, Jens ; Sun, Changquan Calvin ; Rantanen, Jukka. / Expedited investigation of powder caking aided by rapid 3D prototyping of testing devices. In: Journal of Pharmaceutical Sciences. 2020 ; Vol. 109, No. 1. pp. 769-774.

Bibtex

@article{3c6dc98fa79c40d0856d854738ae76b8,
title = "Expedited investigation of powder caking aided by rapid 3D prototyping of testing devices",
abstract = "Powder caking can dramatically affect powder handling and downstream production processes. Understanding the key factors that contribute to bulk powder caking are crucial. This paper introduces the Hirschberg caking device (HCD), which is a 3D printed device allowing for parallel testing of powder caking in a cylindrical geometry. In the HCD set-up, the powder sample is stored in controlled conditions in the sample holder. Upon removal of the sample holder, the caked powder will remain in the shape determined by the sample geometry while the remaining powder will fall down. Caking indices can be calculated based on image analysis and weight measurement. The results obtained for the caking of lactose monohydrate with the HCD were in good agreement with the results obtained by a ring shear tester. Additionally a strain tester was used to measure the strength of the formed cakes. Using this approach, critical storage conditions and the required concentration of a given anti-caking agent (talc) for lactose monohydrate could be identified. This work demonstrates the potential of rapid prototyping in powder characterization by introducing a fast and affordable approach for exploring and trouble-shooting powder caking.",
author = "Cosima Hirschberg and Johan Boetker and Jens Risbo and Sun, {Changquan Calvin} and Jukka Rantanen",
note = "Copyright {\circledC} 2019. Published by Elsevier Inc.",
year = "2020",
doi = "10.1016/j.xphs.2019.07.022",
language = "English",
volume = "109",
pages = "769--774",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Expedited investigation of powder caking aided by rapid 3D prototyping of testing devices

AU - Hirschberg, Cosima

AU - Boetker, Johan

AU - Risbo, Jens

AU - Sun, Changquan Calvin

AU - Rantanen, Jukka

N1 - Copyright © 2019. Published by Elsevier Inc.

PY - 2020

Y1 - 2020

N2 - Powder caking can dramatically affect powder handling and downstream production processes. Understanding the key factors that contribute to bulk powder caking are crucial. This paper introduces the Hirschberg caking device (HCD), which is a 3D printed device allowing for parallel testing of powder caking in a cylindrical geometry. In the HCD set-up, the powder sample is stored in controlled conditions in the sample holder. Upon removal of the sample holder, the caked powder will remain in the shape determined by the sample geometry while the remaining powder will fall down. Caking indices can be calculated based on image analysis and weight measurement. The results obtained for the caking of lactose monohydrate with the HCD were in good agreement with the results obtained by a ring shear tester. Additionally a strain tester was used to measure the strength of the formed cakes. Using this approach, critical storage conditions and the required concentration of a given anti-caking agent (talc) for lactose monohydrate could be identified. This work demonstrates the potential of rapid prototyping in powder characterization by introducing a fast and affordable approach for exploring and trouble-shooting powder caking.

AB - Powder caking can dramatically affect powder handling and downstream production processes. Understanding the key factors that contribute to bulk powder caking are crucial. This paper introduces the Hirschberg caking device (HCD), which is a 3D printed device allowing for parallel testing of powder caking in a cylindrical geometry. In the HCD set-up, the powder sample is stored in controlled conditions in the sample holder. Upon removal of the sample holder, the caked powder will remain in the shape determined by the sample geometry while the remaining powder will fall down. Caking indices can be calculated based on image analysis and weight measurement. The results obtained for the caking of lactose monohydrate with the HCD were in good agreement with the results obtained by a ring shear tester. Additionally a strain tester was used to measure the strength of the formed cakes. Using this approach, critical storage conditions and the required concentration of a given anti-caking agent (talc) for lactose monohydrate could be identified. This work demonstrates the potential of rapid prototyping in powder characterization by introducing a fast and affordable approach for exploring and trouble-shooting powder caking.

U2 - 10.1016/j.xphs.2019.07.022

DO - 10.1016/j.xphs.2019.07.022

M3 - Journal article

C2 - 31386866

VL - 109

SP - 769

EP - 774

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 1

ER -

ID: 225663485