Expedited investigation of powder caking aided by rapid 3D prototyping of testing devices
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Expedited investigation of powder caking aided by rapid 3D prototyping of testing devices. / Hirschberg, Cosima; Boetker, Johan; Risbo, Jens; Sun, Changquan Calvin; Rantanen, Jukka.
In: Journal of Pharmaceutical Sciences, Vol. 109, No. 1, 2020, p. 769-774.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Expedited investigation of powder caking aided by rapid 3D prototyping of testing devices
AU - Hirschberg, Cosima
AU - Boetker, Johan
AU - Risbo, Jens
AU - Sun, Changquan Calvin
AU - Rantanen, Jukka
N1 - Copyright © 2019. Published by Elsevier Inc.
PY - 2020
Y1 - 2020
N2 - Powder caking can dramatically affect powder handling and downstream production processes. Understanding the key factors that contribute to bulk powder caking are crucial. This paper introduces the Hirschberg caking device (HCD), which is a 3D printed device allowing for parallel testing of powder caking in a cylindrical geometry. In the HCD set-up, the powder sample is stored in controlled conditions in the sample holder. Upon removal of the sample holder, the caked powder will remain in the shape determined by the sample geometry while the remaining powder will fall down. Caking indices can be calculated based on image analysis and weight measurement. The results obtained for the caking of lactose monohydrate with the HCD were in good agreement with the results obtained by a ring shear tester. Additionally a strain tester was used to measure the strength of the formed cakes. Using this approach, critical storage conditions and the required concentration of a given anti-caking agent (talc) for lactose monohydrate could be identified. This work demonstrates the potential of rapid prototyping in powder characterization by introducing a fast and affordable approach for exploring and trouble-shooting powder caking.
AB - Powder caking can dramatically affect powder handling and downstream production processes. Understanding the key factors that contribute to bulk powder caking are crucial. This paper introduces the Hirschberg caking device (HCD), which is a 3D printed device allowing for parallel testing of powder caking in a cylindrical geometry. In the HCD set-up, the powder sample is stored in controlled conditions in the sample holder. Upon removal of the sample holder, the caked powder will remain in the shape determined by the sample geometry while the remaining powder will fall down. Caking indices can be calculated based on image analysis and weight measurement. The results obtained for the caking of lactose monohydrate with the HCD were in good agreement with the results obtained by a ring shear tester. Additionally a strain tester was used to measure the strength of the formed cakes. Using this approach, critical storage conditions and the required concentration of a given anti-caking agent (talc) for lactose monohydrate could be identified. This work demonstrates the potential of rapid prototyping in powder characterization by introducing a fast and affordable approach for exploring and trouble-shooting powder caking.
U2 - 10.1016/j.xphs.2019.07.022
DO - 10.1016/j.xphs.2019.07.022
M3 - Journal article
C2 - 31386866
VL - 109
SP - 769
EP - 774
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
SN - 0022-3549
IS - 1
ER -
ID: 225663485