Effects of Water on Powder Flowability of Diverse Powders Assessed by Complimentary Techniques
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Effects of Water on Powder Flowability of Diverse Powders Assessed by Complimentary Techniques. / Hirschberg, Cosima; Sun, Changquan Calvin; Risbo, Jens; Rantanen, Jukka.
In: Journal of Pharmaceutical Sciences, Vol. 108, No. 8, 2019, p. 2613-2620.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Effects of Water on Powder Flowability of Diverse Powders Assessed by Complimentary Techniques
AU - Hirschberg, Cosima
AU - Sun, Changquan Calvin
AU - Risbo, Jens
AU - Rantanen, Jukka
PY - 2019
Y1 - 2019
N2 - The storage of bulk powders in suboptimal conditions can affect their handling, processing, and performance. The aim of this work was to assess the influence of storage conditions on powder flowability, which is a crucial property in powder processing. The 7 model compounds were common tablet excipients with varying crystallinity ranging from amorphous to partially crystalline, and 2 crystalline materials. The water sorption-desorption isotherms of all the excipients were analyzed with dynamic vapor sorption, and the kinetics of the water sorption at 75% relative humidity were investigated using isothermal microcalorimetry. In addition, the powders were conditioned at 3 relative humidities 23%, 43%, and 75% at ambient temperature, and their flowability was measured using 3 different techniques: ring shear testing, basic flowability energy, and flow through an orifice. All 3 methods were able to detect the storage-related change in flowability induced by varying storage conditions. With increasing storage humidity, a trend toward a decrease in powder flowability could be detected with the chosen instruments. Furthermore, the same rank order of powder flowability could be observed using the flow through an orifice and ring shear testing method.
AB - The storage of bulk powders in suboptimal conditions can affect their handling, processing, and performance. The aim of this work was to assess the influence of storage conditions on powder flowability, which is a crucial property in powder processing. The 7 model compounds were common tablet excipients with varying crystallinity ranging from amorphous to partially crystalline, and 2 crystalline materials. The water sorption-desorption isotherms of all the excipients were analyzed with dynamic vapor sorption, and the kinetics of the water sorption at 75% relative humidity were investigated using isothermal microcalorimetry. In addition, the powders were conditioned at 3 relative humidities 23%, 43%, and 75% at ambient temperature, and their flowability was measured using 3 different techniques: ring shear testing, basic flowability energy, and flow through an orifice. All 3 methods were able to detect the storage-related change in flowability induced by varying storage conditions. With increasing storage humidity, a trend toward a decrease in powder flowability could be detected with the chosen instruments. Furthermore, the same rank order of powder flowability could be observed using the flow through an orifice and ring shear testing method.
KW - crystallinity
KW - particle size
KW - powder technology
KW - solid dosage form
KW - water sorption
U2 - 10.1016/j.xphs.2019.03.012
DO - 10.1016/j.xphs.2019.03.012
M3 - Journal article
C2 - 30904477
AN - SCOPUS:85063985680
VL - 108
SP - 2613
EP - 2620
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
SN - 0022-3549
IS - 8
ER -
ID: 217995500