Drug delivery by phospholipase A2 degradable liposomes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Drug delivery by phospholipase A2 degradable liposomes. / Davidsen, Jesper; Vermehren, Charlotte; Frokjaer, Sven; Mouritsen, Ole G.; Jørgensen, Kent.

In: International Journal of Pharmaceutics, Vol. 214, No. 1-2, 19.02.2001, p. 67-69.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Davidsen, J, Vermehren, C, Frokjaer, S, Mouritsen, OG & Jørgensen, K 2001, 'Drug delivery by phospholipase A2 degradable liposomes', International Journal of Pharmaceutics, vol. 214, no. 1-2, pp. 67-69. https://doi.org/10.1016/S0378-5173(00)00634-7

APA

Davidsen, J., Vermehren, C., Frokjaer, S., Mouritsen, O. G., & Jørgensen, K. (2001). Drug delivery by phospholipase A2 degradable liposomes. International Journal of Pharmaceutics, 214(1-2), 67-69. https://doi.org/10.1016/S0378-5173(00)00634-7

Vancouver

Davidsen J, Vermehren C, Frokjaer S, Mouritsen OG, Jørgensen K. Drug delivery by phospholipase A2 degradable liposomes. International Journal of Pharmaceutics. 2001 Feb 19;214(1-2):67-69. https://doi.org/10.1016/S0378-5173(00)00634-7

Author

Davidsen, Jesper ; Vermehren, Charlotte ; Frokjaer, Sven ; Mouritsen, Ole G. ; Jørgensen, Kent. / Drug delivery by phospholipase A2 degradable liposomes. In: International Journal of Pharmaceutics. 2001 ; Vol. 214, No. 1-2. pp. 67-69.

Bibtex

@article{262b0ce418e74a05a73fa7bbdff04524,
title = "Drug delivery by phospholipase A2 degradable liposomes",
abstract = "The effect of poly(ethylene glycol)-phospholipid (PE-PEG) lipopolymers on phospholipase A2 (PLA2) hydrolysis of liposomes composed of stearoyl-oleoylphosphatidylcholine (SOPC) was investigated. The PLA2 lag-time, which is inversely related to the enzymatic activity, was determined by fluorescence, and the zeta-potentials of the liposomes were measured as a function of PE-PEG lipopolymer concentration. A significant decrease in the lag-time, and hence an increase in enzymatic activity, was observed with increasing amounts of the negatively charged PE-PEG lipopolymers incorporated into the SOPC liposomes. The enhancement of the PLA2 enzymatic activity might involve a stronger PLA2 binding affinity towards the negatively charged and polymer covered PEG liposomes.",
keywords = "Degradation, Drug-delivery, Lipopolymer, Liposomes, PEG liposomes, Phospholipase A",
author = "Jesper Davidsen and Charlotte Vermehren and Sven Frokjaer and Mouritsen, {Ole G.} and Kent J{\o}rgensen",
year = "2001",
month = feb,
day = "19",
doi = "10.1016/S0378-5173(00)00634-7",
language = "English",
volume = "214",
pages = "67--69",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Drug delivery by phospholipase A2 degradable liposomes

AU - Davidsen, Jesper

AU - Vermehren, Charlotte

AU - Frokjaer, Sven

AU - Mouritsen, Ole G.

AU - Jørgensen, Kent

PY - 2001/2/19

Y1 - 2001/2/19

N2 - The effect of poly(ethylene glycol)-phospholipid (PE-PEG) lipopolymers on phospholipase A2 (PLA2) hydrolysis of liposomes composed of stearoyl-oleoylphosphatidylcholine (SOPC) was investigated. The PLA2 lag-time, which is inversely related to the enzymatic activity, was determined by fluorescence, and the zeta-potentials of the liposomes were measured as a function of PE-PEG lipopolymer concentration. A significant decrease in the lag-time, and hence an increase in enzymatic activity, was observed with increasing amounts of the negatively charged PE-PEG lipopolymers incorporated into the SOPC liposomes. The enhancement of the PLA2 enzymatic activity might involve a stronger PLA2 binding affinity towards the negatively charged and polymer covered PEG liposomes.

AB - The effect of poly(ethylene glycol)-phospholipid (PE-PEG) lipopolymers on phospholipase A2 (PLA2) hydrolysis of liposomes composed of stearoyl-oleoylphosphatidylcholine (SOPC) was investigated. The PLA2 lag-time, which is inversely related to the enzymatic activity, was determined by fluorescence, and the zeta-potentials of the liposomes were measured as a function of PE-PEG lipopolymer concentration. A significant decrease in the lag-time, and hence an increase in enzymatic activity, was observed with increasing amounts of the negatively charged PE-PEG lipopolymers incorporated into the SOPC liposomes. The enhancement of the PLA2 enzymatic activity might involve a stronger PLA2 binding affinity towards the negatively charged and polymer covered PEG liposomes.

KW - Degradation

KW - Drug-delivery

KW - Lipopolymer

KW - Liposomes

KW - PEG liposomes

KW - Phospholipase A

UR - http://www.scopus.com/inward/record.url?scp=0035910868&partnerID=8YFLogxK

U2 - 10.1016/S0378-5173(00)00634-7

DO - 10.1016/S0378-5173(00)00634-7

M3 - Journal article

C2 - 11282239

AN - SCOPUS:0035910868

VL - 214

SP - 67

EP - 69

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 230987712