Density fluctuations in saturated phospholipid bilayers increase as the acyl-chain length decreases

Research output: Contribution to journalJournal articlepeer-review

A systematic computer simulation study is conducted for a model of the main phase transition of fully hydrated saturated diacyl phosphatidylcholine bilayers (DMPC, DPPC, and DSPC). With particular focus on the fluctuation effects on the thermal properties in the transition region, the study yields data for the specific heat, the lateral compressibility, and the lipid-domain size distribution. Via a simple model assumption the transmembrane passive ion permeability is derived from the lipid-domain interfacial measure. A comparative analysis of the various data shows, in agreement with a number of experiments, that the lateral density fluctuations and hence the response functions increase as the acyl-chain length is decreased.

Original languageEnglish
JournalBiophysical Journal
Volume58
Issue number5
Pages (from-to)1099-1107
Number of pages9
ISSN0006-3495
DOIs
Publication statusPublished - 1990
Externally publishedYes

ID: 236894453