Cell-penetrating peptides for drug delivery across membrane barriers

Research output: Contribution to journalReview

Standard

Cell-penetrating peptides for drug delivery across membrane barriers. / Foged, Camilla; Nielsen, Hanne Moerck.

In: Expert Opinion on Drug Delivery, Vol. 5, No. 1, 2008, p. 105-17.

Research output: Contribution to journalReview

Harvard

Foged, C & Nielsen, HM 2008, 'Cell-penetrating peptides for drug delivery across membrane barriers', Expert Opinion on Drug Delivery, vol. 5, no. 1, pp. 105-17. https://doi.org/10.1517/17425247.5.1.105

APA

Foged, C., & Nielsen, H. M. (2008). Cell-penetrating peptides for drug delivery across membrane barriers. Expert Opinion on Drug Delivery, 5(1), 105-17. https://doi.org/10.1517/17425247.5.1.105

Vancouver

Foged C, Nielsen HM. Cell-penetrating peptides for drug delivery across membrane barriers. Expert Opinion on Drug Delivery. 2008;5(1):105-17. https://doi.org/10.1517/17425247.5.1.105

Author

Foged, Camilla ; Nielsen, Hanne Moerck. / Cell-penetrating peptides for drug delivery across membrane barriers. In: Expert Opinion on Drug Delivery. 2008 ; Vol. 5, No. 1. pp. 105-17.

Bibtex

@article{802e5640e88f11dcbee902004c4f4f50,
title = "Cell-penetrating peptides for drug delivery across membrane barriers",
abstract = "During the last decade, cell-penetrating peptides have been investigated for their ability to overcome the plasma membrane barrier of mammalian cells for the intracellular or transcellular delivery of cargoes as diverse as low molecular weight drugs, imaging agents, oligonucleotides, peptides, proteins and colloidal carriers such as liposomes and polymeric nanoparticles. Their ability to cross biological membranes in a non-disruptive way without apparent toxicity is highly desired for increasing drug bioavailability. This review provides an overview of the application of cell-penetrating peptides as transmembrane drug delivery agents, according to the recent literature, and discusses critical issues and future challenges in relation to fully understanding the fundamental principles of the cell-penetrating peptide-mediated membrane translocation of cargoes and the exploitation of their therapeutic potential.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Camilla Foged and Nielsen, {Hanne Moerck}",
year = "2008",
doi = "10.1517/17425247.5.1.105",
language = "English",
volume = "5",
pages = "105--17",
journal = "Expert Opinion on Drug Delivery",
issn = "1742-5247",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - Cell-penetrating peptides for drug delivery across membrane barriers

AU - Foged, Camilla

AU - Nielsen, Hanne Moerck

PY - 2008

Y1 - 2008

N2 - During the last decade, cell-penetrating peptides have been investigated for their ability to overcome the plasma membrane barrier of mammalian cells for the intracellular or transcellular delivery of cargoes as diverse as low molecular weight drugs, imaging agents, oligonucleotides, peptides, proteins and colloidal carriers such as liposomes and polymeric nanoparticles. Their ability to cross biological membranes in a non-disruptive way without apparent toxicity is highly desired for increasing drug bioavailability. This review provides an overview of the application of cell-penetrating peptides as transmembrane drug delivery agents, according to the recent literature, and discusses critical issues and future challenges in relation to fully understanding the fundamental principles of the cell-penetrating peptide-mediated membrane translocation of cargoes and the exploitation of their therapeutic potential.

AB - During the last decade, cell-penetrating peptides have been investigated for their ability to overcome the plasma membrane barrier of mammalian cells for the intracellular or transcellular delivery of cargoes as diverse as low molecular weight drugs, imaging agents, oligonucleotides, peptides, proteins and colloidal carriers such as liposomes and polymeric nanoparticles. Their ability to cross biological membranes in a non-disruptive way without apparent toxicity is highly desired for increasing drug bioavailability. This review provides an overview of the application of cell-penetrating peptides as transmembrane drug delivery agents, according to the recent literature, and discusses critical issues and future challenges in relation to fully understanding the fundamental principles of the cell-penetrating peptide-mediated membrane translocation of cargoes and the exploitation of their therapeutic potential.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1517/17425247.5.1.105

DO - 10.1517/17425247.5.1.105

M3 - Review

C2 - 18095931

VL - 5

SP - 105

EP - 117

JO - Expert Opinion on Drug Delivery

JF - Expert Opinion on Drug Delivery

SN - 1742-5247

IS - 1

ER -

ID: 2967715