TY - JOUR

T1 - Cardiac perfusion and function after high-intensity exercise training in late premenopausal and recent postmenopausal women

T2 - An MRI study

AU - Egelund, Jon

AU - Nyberg, Michael Permin

AU - Mandrup, Camilla M

AU - Abdulla, Jawdat

AU - Stallknecht, Bente

AU - Bangsbo, Jens

AU - Hellsten, Ylva

AU - Larsson, Henrik Bo Wiberg

N1 - CURIS 2019 NEXS 164

PY - 2019

Y1 - 2019

N2 - Background: We examined the influence of recent menopause and aerobic exercise training in women on myocardial perfusion, left ventricular (LV) dimension and function.Methods: Two groups (n=14 each) of healthy late pre- (50.2±2.1 years) and recent postmenopausal (54.2±2.8 years) women underwent cardiac magnetic resonance imaging (cMRI) at baseline and after 12-weeks of high-intensity aerobic training. Measurements included LV morphology, systolic function and myocardial perfusion at rest and during an adenosine stress test,.Results: At baseline, resting myocardial perfusion was lower in the post- than the premenopausal group (77±3 vs. 89±3 ml/100g/min; p=0.01), while adenosine induced myocardial perfusion was not different (p=0.81). After exercise training, resting myocardial perfusion was lower in both groups (66±2; p=0.002 vs 81±3 ml/100g/min; p=0.03). The adenosine induced change in myocardial perfusion was lower in the groups combined (by 402±17 ml/100g/min; p=0.02) and the adenosine induced increase ín heart rate was 10±2 bpm lower (p<0.0001) after training in both groups. Normalization of myocardial perfusion using an estimate of cardiac work, eliminated the differences in perfusion between the pre and postmenopausal groups and the effect of training. LV mass was higher in both groups (p=0.03; p=0.006) whereas LV end-diastolic (p=0.02) and stroke (p=0.045) volume were higher in the postmenopausal group after training.Conclusions: Twelve weeks of exercise training increased LV mass and lowered resting and adenosine induced myocardial perfusion, an effect which was likely related to cardiac work. The current data also suggests that the early menopausal transition has limited impact on cardiac function and structure.

AB - Background: We examined the influence of recent menopause and aerobic exercise training in women on myocardial perfusion, left ventricular (LV) dimension and function.Methods: Two groups (n=14 each) of healthy late pre- (50.2±2.1 years) and recent postmenopausal (54.2±2.8 years) women underwent cardiac magnetic resonance imaging (cMRI) at baseline and after 12-weeks of high-intensity aerobic training. Measurements included LV morphology, systolic function and myocardial perfusion at rest and during an adenosine stress test,.Results: At baseline, resting myocardial perfusion was lower in the post- than the premenopausal group (77±3 vs. 89±3 ml/100g/min; p=0.01), while adenosine induced myocardial perfusion was not different (p=0.81). After exercise training, resting myocardial perfusion was lower in both groups (66±2; p=0.002 vs 81±3 ml/100g/min; p=0.03). The adenosine induced change in myocardial perfusion was lower in the groups combined (by 402±17 ml/100g/min; p=0.02) and the adenosine induced increase ín heart rate was 10±2 bpm lower (p<0.0001) after training in both groups. Normalization of myocardial perfusion using an estimate of cardiac work, eliminated the differences in perfusion between the pre and postmenopausal groups and the effect of training. LV mass was higher in both groups (p=0.03; p=0.006) whereas LV end-diastolic (p=0.02) and stroke (p=0.045) volume were higher in the postmenopausal group after training.Conclusions: Twelve weeks of exercise training increased LV mass and lowered resting and adenosine induced myocardial perfusion, an effect which was likely related to cardiac work. The current data also suggests that the early menopausal transition has limited impact on cardiac function and structure.

KW - Faculty of Science

KW - Myocardial perfusion

KW - Menopause

KW - Cardiac MRI

KW - Exercise

U2 - 10.1152/japplphysiol.01089.2017

DO - 10.1152/japplphysiol.01089.2017

M3 - Journal article

C2 - 30870082

VL - 126

SP - 1272

EP - 1280

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 5

ER -