Bioavailability of seocalcitol IV: evaluation of lymphatic transport in conscious rats

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Bioavailability of seocalcitol IV : evaluation of lymphatic transport in conscious rats. / Grove, Mette; Nielsen, Jeanet L; Pedersen, Gitte P; Müllertz, Anette.

In: Pharmaceutical Research, Vol. 23, No. 11, 2006, p. 2681-8.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Grove, M, Nielsen, JL, Pedersen, GP & Müllertz, A 2006, 'Bioavailability of seocalcitol IV: evaluation of lymphatic transport in conscious rats', Pharmaceutical Research, vol. 23, no. 11, pp. 2681-8. https://doi.org/10.1007/s11095-006-9109-z

APA

Grove, M., Nielsen, J. L., Pedersen, G. P., & Müllertz, A. (2006). Bioavailability of seocalcitol IV: evaluation of lymphatic transport in conscious rats. Pharmaceutical Research, 23(11), 2681-8. https://doi.org/10.1007/s11095-006-9109-z

Vancouver

Grove M, Nielsen JL, Pedersen GP, Müllertz A. Bioavailability of seocalcitol IV: evaluation of lymphatic transport in conscious rats. Pharmaceutical Research. 2006;23(11):2681-8. https://doi.org/10.1007/s11095-006-9109-z

Author

Grove, Mette ; Nielsen, Jeanet L ; Pedersen, Gitte P ; Müllertz, Anette. / Bioavailability of seocalcitol IV : evaluation of lymphatic transport in conscious rats. In: Pharmaceutical Research. 2006 ; Vol. 23, No. 11. pp. 2681-8.

Bibtex

@article{ca91e860c5e711dd9473000ea68e967b,
title = "Bioavailability of seocalcitol IV: evaluation of lymphatic transport in conscious rats",
abstract = "PURPOSE: To study the use of long chain triglycerides (LCT) as a lymphotropic carrier of (3)H-seocalcitol by comparing the lymphatic transport and the portal absorption of (3)H-seocalcitol when dissolved in a (1) LCT solution or a (2) reference solution without lipid containing propylene glycol (PG). MATERIALS AND METHODS: A lymph cannulated conscious rat model was dosed orally with (3)H-seocalcitol dissolved in either LCT or PG. Lymph was collected continuously, and blood was sampled over 9 h. (3)H-seocalcitol in blood and lymph and triglycerides in lymph were analysed. RESULTS: A statistically significantly (p < 0.05) higher recovery of the dosed (3)H-seocalcitol was found in the intestinal lymph upon administration of the LCT solution (1.3 +/- 0.6{\%}) compared to the PG solution (0.5 +/- 0.4{\%}). The portal absorption of (3)H-seocalcitol was significantly (p < 0.05) higher from the LCT solution (16.2 +/- 2.2{\%}) than from the PG solution (10.8 +/- 0.8{\%}). CONCLUSIONS: The LCT solution resulted in a statistical significantly higher level of lymphatic and portal transport of (3)H-seocalcitol compared with the PG solution. However, even though LCT facilitates the formation of chylomicrons, (3)H-seocalcitol favours absorption directly to the portal blood probably due to the moderate lipophilicity of the molecule.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Mette Grove and Nielsen, {Jeanet L} and Pedersen, {Gitte P} and Anette M{\"u}llertz",
note = "Keywords: Animals; Biological Availability; Biological Transport; Calcitriol; Gastrointestinal Tract; Lymph; Rats; Triglycerides",
year = "2006",
doi = "10.1007/s11095-006-9109-z",
language = "English",
volume = "23",
pages = "2681--8",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "Springer",
number = "11",

}

RIS

TY - JOUR

T1 - Bioavailability of seocalcitol IV

T2 - evaluation of lymphatic transport in conscious rats

AU - Grove, Mette

AU - Nielsen, Jeanet L

AU - Pedersen, Gitte P

AU - Müllertz, Anette

N1 - Keywords: Animals; Biological Availability; Biological Transport; Calcitriol; Gastrointestinal Tract; Lymph; Rats; Triglycerides

PY - 2006

Y1 - 2006

N2 - PURPOSE: To study the use of long chain triglycerides (LCT) as a lymphotropic carrier of (3)H-seocalcitol by comparing the lymphatic transport and the portal absorption of (3)H-seocalcitol when dissolved in a (1) LCT solution or a (2) reference solution without lipid containing propylene glycol (PG). MATERIALS AND METHODS: A lymph cannulated conscious rat model was dosed orally with (3)H-seocalcitol dissolved in either LCT or PG. Lymph was collected continuously, and blood was sampled over 9 h. (3)H-seocalcitol in blood and lymph and triglycerides in lymph were analysed. RESULTS: A statistically significantly (p < 0.05) higher recovery of the dosed (3)H-seocalcitol was found in the intestinal lymph upon administration of the LCT solution (1.3 +/- 0.6%) compared to the PG solution (0.5 +/- 0.4%). The portal absorption of (3)H-seocalcitol was significantly (p < 0.05) higher from the LCT solution (16.2 +/- 2.2%) than from the PG solution (10.8 +/- 0.8%). CONCLUSIONS: The LCT solution resulted in a statistical significantly higher level of lymphatic and portal transport of (3)H-seocalcitol compared with the PG solution. However, even though LCT facilitates the formation of chylomicrons, (3)H-seocalcitol favours absorption directly to the portal blood probably due to the moderate lipophilicity of the molecule.

AB - PURPOSE: To study the use of long chain triglycerides (LCT) as a lymphotropic carrier of (3)H-seocalcitol by comparing the lymphatic transport and the portal absorption of (3)H-seocalcitol when dissolved in a (1) LCT solution or a (2) reference solution without lipid containing propylene glycol (PG). MATERIALS AND METHODS: A lymph cannulated conscious rat model was dosed orally with (3)H-seocalcitol dissolved in either LCT or PG. Lymph was collected continuously, and blood was sampled over 9 h. (3)H-seocalcitol in blood and lymph and triglycerides in lymph were analysed. RESULTS: A statistically significantly (p < 0.05) higher recovery of the dosed (3)H-seocalcitol was found in the intestinal lymph upon administration of the LCT solution (1.3 +/- 0.6%) compared to the PG solution (0.5 +/- 0.4%). The portal absorption of (3)H-seocalcitol was significantly (p < 0.05) higher from the LCT solution (16.2 +/- 2.2%) than from the PG solution (10.8 +/- 0.8%). CONCLUSIONS: The LCT solution resulted in a statistical significantly higher level of lymphatic and portal transport of (3)H-seocalcitol compared with the PG solution. However, even though LCT facilitates the formation of chylomicrons, (3)H-seocalcitol favours absorption directly to the portal blood probably due to the moderate lipophilicity of the molecule.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1007/s11095-006-9109-z

DO - 10.1007/s11095-006-9109-z

M3 - Journal article

C2 - 17048118

VL - 23

SP - 2681

EP - 2688

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 11

ER -

ID: 9010043