ApoE-dependent protective effects of sesamol on high-fat diet-induced behavioral disorders: regulation of the microbiome-gut-brain axis

Research output: Contribution to journalJournal articleResearchpeer-review

Tian Yuan, Chuanqi Chu, Rubing Shi, Tianlin Cui, Xinglin Zhang, Yihang Zhao, Xu Shi, Yan Hui, Junru Pan, Rui Qian, Xiaoshuang Dai, Zhigang Liu, Xuebo Liu

Sesamol, an antioxidant lignan from sesame oil, possesses neuroprotective bioactivities. The present work was aimed to elucidate the systemic protective effects of sesamol on cognitive deficits, and to determine the possible link between gut and brain. Wildtype and ApoE-/- mice were treated with a high-fat diet and sesamol (0.05%, w/w, in drinking water) for 10 weeks. Behavioral tests including Morris-water maze, Y-maze, and elevated plus maze tests indicated that sesamol could only improve cognitive deficits and anxiety behaviors in wildtype. Consistently, sesamol improved synapse ultrastructure and inhibited Aβ accumulation in an ApoE-dependent manner. Moreover, sesamol prevented dietary-induced gut barrier damages and systemic inflammation. Sesamol also re-shaped gut microbiome and improved the generation of microbial metabolites short chain fatty acids. To summarized, this study revealed that the possible mechanism of neuroprotective effects of sesamol might be ApoE-dependent, and its beneficial effects on gut microbiota/metabolites could be translated into neurodegenerative diseases treatment.

Original languageEnglish
JournalJournal of Agricultural and Food Chemistry
Volume67
Issue number22
Pages (from-to)6190-6201
ISSN0021-8561
DOIs
Publication statusPublished - 2019

ID: 218588329