ApoE-dependent protective effects of sesamol on high-fat diet-induced behavioral disorders: regulation of the microbiome-gut-brain axis

Research output: Contribution to journalJournal articlepeer-review

Standard

ApoE-dependent protective effects of sesamol on high-fat diet-induced behavioral disorders : regulation of the microbiome-gut-brain axis. / Yuan, Tian; Chu, Chuanqi; Shi, Rubing; Cui, Tianlin; Zhang, Xinglin; Zhao, Yihang; Shi, Xu; Hui, Yan; Pan, Junru; Qian, Rui; Dai, Xiaoshuang; Liu, Zhigang; Liu, Xuebo.

In: Journal of Agricultural and Food Chemistry, Vol. 67, No. 22, 2019, p. 6190-6201.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Yuan, T, Chu, C, Shi, R, Cui, T, Zhang, X, Zhao, Y, Shi, X, Hui, Y, Pan, J, Qian, R, Dai, X, Liu, Z & Liu, X 2019, 'ApoE-dependent protective effects of sesamol on high-fat diet-induced behavioral disorders: regulation of the microbiome-gut-brain axis', Journal of Agricultural and Food Chemistry, vol. 67, no. 22, pp. 6190-6201. https://doi.org/10.1021/acs.jafc.9b01436

APA

Yuan, T., Chu, C., Shi, R., Cui, T., Zhang, X., Zhao, Y., Shi, X., Hui, Y., Pan, J., Qian, R., Dai, X., Liu, Z., & Liu, X. (2019). ApoE-dependent protective effects of sesamol on high-fat diet-induced behavioral disorders: regulation of the microbiome-gut-brain axis. Journal of Agricultural and Food Chemistry, 67(22), 6190-6201. https://doi.org/10.1021/acs.jafc.9b01436

Vancouver

Yuan T, Chu C, Shi R, Cui T, Zhang X, Zhao Y et al. ApoE-dependent protective effects of sesamol on high-fat diet-induced behavioral disorders: regulation of the microbiome-gut-brain axis. Journal of Agricultural and Food Chemistry. 2019;67(22):6190-6201. https://doi.org/10.1021/acs.jafc.9b01436

Author

Yuan, Tian ; Chu, Chuanqi ; Shi, Rubing ; Cui, Tianlin ; Zhang, Xinglin ; Zhao, Yihang ; Shi, Xu ; Hui, Yan ; Pan, Junru ; Qian, Rui ; Dai, Xiaoshuang ; Liu, Zhigang ; Liu, Xuebo. / ApoE-dependent protective effects of sesamol on high-fat diet-induced behavioral disorders : regulation of the microbiome-gut-brain axis. In: Journal of Agricultural and Food Chemistry. 2019 ; Vol. 67, No. 22. pp. 6190-6201.

Bibtex

@article{e4d853893bf64606857060f205cc2c91,
title = "ApoE-dependent protective effects of sesamol on high-fat diet-induced behavioral disorders: regulation of the microbiome-gut-brain axis",
abstract = "Sesamol, an antioxidant lignan from sesame oil, possesses neuroprotective bioactivities. The present work was aimed to elucidate the systemic protective effects of sesamol on cognitive deficits, and to determine the possible link between gut and brain. Wildtype and ApoE-/- mice were treated with a high-fat diet and sesamol (0.05%, w/w, in drinking water) for 10 weeks. Behavioral tests including Morris-water maze, Y-maze, and elevated plus maze tests indicated that sesamol could only improve cognitive deficits and anxiety behaviors in wildtype. Consistently, sesamol improved synapse ultrastructure and inhibited Aβ accumulation in an ApoE-dependent manner. Moreover, sesamol prevented dietary-induced gut barrier damages and systemic inflammation. Sesamol also re-shaped gut microbiome and improved the generation of microbial metabolites short chain fatty acids. To summarized, this study revealed that the possible mechanism of neuroprotective effects of sesamol might be ApoE-dependent, and its beneficial effects on gut microbiota/metabolites could be translated into neurodegenerative diseases treatment.",
author = "Tian Yuan and Chuanqi Chu and Rubing Shi and Tianlin Cui and Xinglin Zhang and Yihang Zhao and Xu Shi and Yan Hui and Junru Pan and Rui Qian and Xiaoshuang Dai and Zhigang Liu and Xuebo Liu",
year = "2019",
doi = "10.1021/acs.jafc.9b01436",
language = "English",
volume = "67",
pages = "6190--6201",
journal = "Journal of Agricultural and Food Chemistry",
issn = "0021-8561",
publisher = "American Chemical Society",
number = "22",

}

RIS

TY - JOUR

T1 - ApoE-dependent protective effects of sesamol on high-fat diet-induced behavioral disorders

T2 - regulation of the microbiome-gut-brain axis

AU - Yuan, Tian

AU - Chu, Chuanqi

AU - Shi, Rubing

AU - Cui, Tianlin

AU - Zhang, Xinglin

AU - Zhao, Yihang

AU - Shi, Xu

AU - Hui, Yan

AU - Pan, Junru

AU - Qian, Rui

AU - Dai, Xiaoshuang

AU - Liu, Zhigang

AU - Liu, Xuebo

PY - 2019

Y1 - 2019

N2 - Sesamol, an antioxidant lignan from sesame oil, possesses neuroprotective bioactivities. The present work was aimed to elucidate the systemic protective effects of sesamol on cognitive deficits, and to determine the possible link between gut and brain. Wildtype and ApoE-/- mice were treated with a high-fat diet and sesamol (0.05%, w/w, in drinking water) for 10 weeks. Behavioral tests including Morris-water maze, Y-maze, and elevated plus maze tests indicated that sesamol could only improve cognitive deficits and anxiety behaviors in wildtype. Consistently, sesamol improved synapse ultrastructure and inhibited Aβ accumulation in an ApoE-dependent manner. Moreover, sesamol prevented dietary-induced gut barrier damages and systemic inflammation. Sesamol also re-shaped gut microbiome and improved the generation of microbial metabolites short chain fatty acids. To summarized, this study revealed that the possible mechanism of neuroprotective effects of sesamol might be ApoE-dependent, and its beneficial effects on gut microbiota/metabolites could be translated into neurodegenerative diseases treatment.

AB - Sesamol, an antioxidant lignan from sesame oil, possesses neuroprotective bioactivities. The present work was aimed to elucidate the systemic protective effects of sesamol on cognitive deficits, and to determine the possible link between gut and brain. Wildtype and ApoE-/- mice were treated with a high-fat diet and sesamol (0.05%, w/w, in drinking water) for 10 weeks. Behavioral tests including Morris-water maze, Y-maze, and elevated plus maze tests indicated that sesamol could only improve cognitive deficits and anxiety behaviors in wildtype. Consistently, sesamol improved synapse ultrastructure and inhibited Aβ accumulation in an ApoE-dependent manner. Moreover, sesamol prevented dietary-induced gut barrier damages and systemic inflammation. Sesamol also re-shaped gut microbiome and improved the generation of microbial metabolites short chain fatty acids. To summarized, this study revealed that the possible mechanism of neuroprotective effects of sesamol might be ApoE-dependent, and its beneficial effects on gut microbiota/metabolites could be translated into neurodegenerative diseases treatment.

U2 - 10.1021/acs.jafc.9b01436

DO - 10.1021/acs.jafc.9b01436

M3 - Journal article

C2 - 31117496

VL - 67

SP - 6190

EP - 6201

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

SN - 0021-8561

IS - 22

ER -

ID: 218588329