An outlook on organization of lipids in membranes: Searching for a realistic connection with the organization of biological membranes
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An outlook on organization of lipids in membranes : Searching for a realistic connection with the organization of biological membranes. / Bagatolli, Luis A.; Ipsen, John H.; Simonsen, Adam C.; Mouritsen, Ole G.
In: Progress in Lipid Research, Vol. 49, No. 4, 01.10.2010, p. 378-389.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - An outlook on organization of lipids in membranes
T2 - Searching for a realistic connection with the organization of biological membranes
AU - Bagatolli, Luis A.
AU - Ipsen, John H.
AU - Simonsen, Adam C.
AU - Mouritsen, Ole G.
PY - 2010/10/1
Y1 - 2010/10/1
N2 - Lipid-bilayer membranes are formed by self-assembly processes. The molecular interactions within the bilayer and with the environment impart a unique trans-bilayer lateral pressure profile and provide a set of physical mechanisms for formation of lipid domains and laterally differentiated regions in the plane of the membrane. Results from a number of experimental and theoretical studies of model lipid bilayers are reviewed, emphasizing the significance of these fundamental physical properties for the structure and dynamics of biological membranes. Particular attention is paid to the relevance of postulating the existence of equilibrium thermodynamic phases in biological membranes. This includes a discussion of the possible significance of equilibrium critical points in biological membrane systems that normally exist under non-equilibrium conditions. The need for a new model to replace the celebrated Nicolson-Singer fluid-mosaic model of biological membranes is also discussed.
AB - Lipid-bilayer membranes are formed by self-assembly processes. The molecular interactions within the bilayer and with the environment impart a unique trans-bilayer lateral pressure profile and provide a set of physical mechanisms for formation of lipid domains and laterally differentiated regions in the plane of the membrane. Results from a number of experimental and theoretical studies of model lipid bilayers are reviewed, emphasizing the significance of these fundamental physical properties for the structure and dynamics of biological membranes. Particular attention is paid to the relevance of postulating the existence of equilibrium thermodynamic phases in biological membranes. This includes a discussion of the possible significance of equilibrium critical points in biological membrane systems that normally exist under non-equilibrium conditions. The need for a new model to replace the celebrated Nicolson-Singer fluid-mosaic model of biological membranes is also discussed.
KW - Biological membrane model
KW - Equilibrium thermodynamic phases
KW - Lateral pressure profile
KW - Membrane domains
KW - Non equilibrium phenomena
KW - Trans-bilayer structure
UR - http://www.scopus.com/inward/record.url?scp=77956393723&partnerID=8YFLogxK
U2 - 10.1016/j.plipres.2010.05.001
DO - 10.1016/j.plipres.2010.05.001
M3 - Review
C2 - 20478336
AN - SCOPUS:77956393723
VL - 49
SP - 378
EP - 389
JO - Progress in Lipid Research
JF - Progress in Lipid Research
SN - 0163-7827
IS - 4
ER -
ID: 230976187