Activation of interfacial enzymes at membrane surfaces

Research output: Contribution to journalJournal articleResearchpeer-review

  • Mouritsen, Ole G.
  • Thomas L. Andresen
  • Avi Halperin
  • Hansen, Per
  • Ask F. Jakobsen
  • Uffe Bernchou Jensen
  • Morten Jensen
  • Kent Jørgensen
  • Thomas Kaasgaard
  • Chad Leidy
  • Adam Cohen Simonsen
  • Günther H. Peters
  • Matthias Weiss

A host of water-soluble enzymes are active at membrane surfaces and in association with membranes. Some of these enzymes are involved in signalling and in modification and remodelling of the membranes. A special class of enzymes, the phospholipases, and in particular secretory phospholipase A2 (sPLA2), are only activated at the interface between water and membrane surfaces, where they lead to a break-down of the lipid molecules into lysolipids and free fatty acids. The activation is critically dependent on the physical properties of the lipid-membrane substrate. A topical review is given of our current understanding of the physical mechanisms responsible for activation of sPLA2 as derived from a range of different experimental and theoretical investigations.

Original languageEnglish
Article numberS12
JournalJournal of Physics Condensed Matter
Issue number28
Pages (from-to)S1293-S1304
Publication statusPublished - 19 Jul 2006

ID: 230978053