Ling Deng

Ling Deng

Associate Professor


  1. 2024
  2. Published

    Escherichia coli CRISPR arrays from early life fecal samples preferentially target prophages

    Dion, M. B., Shah, S. A., Deng, Ling, Thorsen, Jonathan Jan Ilve, Stokholm, Jakob, Krogfelt, K. A., Schjørring, S., Horvath, P., Allard, A., Nielsen, Dennis Sandris, Petit, M. A. & Moineau, S., 2024, In: The ISME Journal. 18, 1, 9 p., wrae005.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2023
  4. Published

    CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice

    Rasmussen, Torben Sølbeck, Koefoed, A. K., Deng, Ling, Muhammed, Musemma Kedir, Rousseau, G. M., Kot, Witold, Sprotte, S., Neve, H., Franz, C. M. A. P., Hansen, Axel Kornerup, Vogensen, Finn Kvist, Moineau, S. & Nielsen, Dennis Sandris, 2023, In: ISME Journal. 17, p. 432–442

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Cesarean section induced dysbiosis promotes type 2 immunity but not oxazolone-induced dermatitis in mice

    Zachariassen, L. F., Ebert, M. B. B., Mentzel, Caroline M. Junker, Deng, Ling, Krych, Lukasz, Nielsen, Dennis Sandris, Stokholm, Jakob & Hansen, Camilla Hartmann Friis, 2023, In: Gut Microbes. 15, 2, 15 p., 2271151.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Choice of Ultrafilter Affects Recovery Rate of Bacteriophages

    Larsen, Frej Andreas Nøhr, Offersen, Simone Margaard, Li, V. R., Deng, Ling, Nielsen, Dennis Sandris & Rasmussen, Torben Sølbeck, 2023, In: Viruses. 15, 10, 12 p., 2051.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Expanding known viral diversity in the healthy infant gut

    Shah, S. A., Deng, L., Thorsen, J., Pedersen, A. G., Dion, M. B., Castro-Mejía, J. L., Silins, R., Romme, F. O., Sausset, R., Jessen, L. E., Ndela, E. O., Hjelmsø, M., Rasmussen, M. A., Redgwell, T. A., Rodríguez, C. L., Vestergaard, G., Zhang, Y., Chawes, B., Bønnelykke, K., Sørensen, S. J. & 6 others, Bisgaard, H., Enault, F., Stokholm, Jakob, Moineau, S., Petit, M. A. & Nielsen, Dennis Sandris, 2023, In: Nature Microbiology. 8, p. 986–998

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Replication Protein Rep Provides Selective Advantage to Viruses in the Presence of CRISPR-Cas Immunity

    Zhang, W., Bhoobalan-Chitty, Y., Zhai, Xichuan, Hui, Y., Hansen, Lars Hestbjerg, Deng, Ling & Peng, Xu, 2023, In: CRISPR Journal. 6, 1, p. 32-42

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The impact of storage buffer and storage conditions on fecal samples for bacteriophage infectivity and metavirome analyses

    Zhai, Xichuan, Castro-Mejía, J. L., Gobbi, Alex, Aslampaloglou, A., Kot, Witold, Nielsen, Dennis Sandris & Deng, Ling, 2023, In: Microbiome. 11, 12 p., 193.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The infant gut virome is associated with preschool asthma risk independently of bacteria

    Rodríguez, C. L., Shah, S. A., Rasmussen, Morten Arendt, Thorsen, J., Boulund, U., Pedersen, C. T., Castro-Mejía, J. L., Poulsen, Christina Egeø, Poulsen, C. S., Deng, Ling, Larsen, Frej Andreas Nøhr, Widdowson, Michael Lawrence, Zhang, Yichang, Sørensen, Søren Johannes, Moineau, S., Petit, M. A., Chawes, Bo Lund Krogsgaard, Bønnelykke, Klaus, Nielsen, Dennis Sandris & Stokholm, Jakob, 2023, In: Nature Medicine. 30, p. 138-148 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2022
  12. Published

    Donor-dependent fecal microbiota transplantation efficacy against necrotizing enterocolitis in preterm pigs

    Hui, Y., Vestergaard, G., Deng, Ling, Kot, Witold, Thymann, Thomas, Brunse, Anders & Nielsen, Dennis Sandris, 2022, In: npj Biofilms and Microbiomes. 8, 1, 12 p., 48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Effect of gluten-free diet and antibiotics on murine gut microbiota and immune response to tetanus vaccination

    Kihl, Pernille, Krych, Lukasz, Deng, Ling, Hansen, Lars Hestbjerg, Buschard, K., Skov, Søren, Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2022, In: Plos One. 17, 4, 21 p., e0266719.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Fecal filtrate transplantation protects against necrotizing enterocolitis

    Brunse, Anders, Deng, Ling, Pan, X., Hui, Y., Castro Mejia, J. L., Kot, Witold, Nguyen, Duc Ninh, Secher, Jan Bojsen-Møller, Nielsen, Dennis Sandris & Thymann, Thomas, 2022, In: The ISME Journal. 16, p. 686–694

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Genome binning of viral entities from bulk metagenomics data

    Johansen, Joachim, Plichta, D. R., Nissen, J. N., Jespersen, Marie Louise, Shah, S. A., Deng, Ling, Stokholm, Jakob, Bisgaard, H., Nielsen, Dennis Sandris, Sørensen, Søren Johannes & Rasmussen, Simon, 2022, In: Nature Communications. 13, 12 p., 965.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 2021
  17. Published

    Enteral broad-spectrum antibiotics antagonize the effect of fecal microbiota transplantation in preterm pigs

    Brunse, Anders, Offersen, Simone Margaard, Mosegaard, J. J., Deng, Ling, Damborg, Peter Panduro, Nielsen, Dennis Sandris, Sangild, Per Torp, Thymann, Thomas & Nguyen, Duc Ninh, 2021, In: Gut Microbes. 13, 1, p. 1-16 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. 2020
  19. Published

    Bacteriophage-mediated manipulation of the gut microbiome - promises and presents limitations

    Rasmussen, Torben Sølbeck, Koefoed, A. K., Jakobsen, Rasmus Riemer, Deng, Ling, Castro-Mejía, J. L., Brunse, Anders, Neve, H., Vogensen, Finn Kvist & Nielsen, Dennis Sandris, 2020, In: FEMS Microbiology Reviews. 44, 4, p. 507-521 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

  20. Published

    Characterization of the Vaginal DNA Virome in Health and Dysbiosis

    Jakobsen, Rasmus Riemer, Haahr, T., Humaidan, P., Jensen, J. S., Kot, Witold, Castro-Mejia, J. L., Deng, Ling, Leser, T. D. & Nielsen, Dennis Sandris, 2020, In: Viruses. 12, 10, 13 p., 1143.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Virulent coliphages in 1-year-old children fecal samples are fewer, but more infectious than temperate coliphages

    Mathieu, A., Dion, M., Deng, Ling, Tremblay, D., Moncaut, E., Shah, S. A., Stokholm, Jakob, Krogfelt, K. A., Schjørring, S., Bisgaard, H., Nielsen, Dennis Sandris, Moineau, S. & Petit, M., 2020, In: Nature Communications. 11, 12 p., 378.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2019
  23. Published

    A Protocol for Extraction of Infective Viromes Suitable for Metagenomics Sequencing from Low Volume Fecal Samples

    Deng, Ling, Silins, R., Castro-Mejia, J. L., Kot, W., Jessen, L., Thorsen, J., Shah, S., Stokholm, Jakob, Bisgaard, H., Moineau, S. & Nielsen, Dennis Sandris, 2019, In: Viruses. 11, 7, 10 p., 667.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    A seed motif for target RNA capture enables efficient immune defence by a type III-B CRISPR-Cas system

    Pan, S., Li, Q., Deng, Ling, Jiang, S., Jin, X., Peng, N., Liang, Y., She, Q. & Li, Y., 2019, In: RNA Biology. 16, 9, p. 1166-1178

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Oral LPS Dosing Induces Local Immunological Changes in the Pancreatic Lymph Nodes in Mice

    Kihl, Pernille, Krych, Lukasz, Deng, Ling, Kildemoes, A. O., Laigaard, A., Hansen, L. H., Hansen, Camilla Hartmann Friis, Buschard, K., Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2019, In: Journal of Diabetes Research. 2019, 9 p., 1649279.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2018
  27. Published
  28. Published

    Extraction and purification of viruses from fecal samples for metagenome and morphology analyses

    Castro-Mejía, J. L., Deng, Ling, Vogensen, Finn Kvist, Reyes, A. & Nielsen, Dennis Sandris, 2018, The Human Virome: Methods and Protocols. Moya, A. & Brocal, V. P. (eds.). Humana Press, p. 49-57 9 p. (Methods in Molecular Biology, Vol. 1838).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  29. 2017
  30. Published

    Formation of a viral replication focus in Sulfolobus cells infected by the rudivirus Sulfolobus islandicus rod-shaped virus 2

    Martinez Alvarez, Laura, Deng, Ling & Peng, Xu, Jul 2017, In: Journal of Virology. 91, 13, 12 p., e00486-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    A type III-B CRISPR-Cas effector complex mediating massive target DNA destruction

    Han, W., Li, Y., Deng, Ling, Feng, M., Peng, W., Hallstrøm, S., Zhang, J., Peng, N., Liang, Y. X., White, M. F. & She, Q., 2017, In: Nucleic Acids Research. 45, 4, p. 1983–1993 11 p., gkw1274.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. 2016
  33. Published

    Major and minor crRNA annealing sites facilitate low stringency DNA protospacer binding prior to Type I-A CRISPR-Cas interference in Sulfolobus

    Mousaei, M., Deng, Ling, She, Q. & Garrett, Roger Antony, 2016, In: R N A Biology. 13, 11, p. 1166-1173 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2015
  35. Published

    CRISPR-Cas adaptive immune systems of the sulfolobales: unravelling their complexity and diversity

    Garrett, Roger Antony, Shah, S. A., Erdmann, S., Guannan, L., Mousaei, M., León Sobrino, C., Peng, W., Islin, S. R., Deng, Ling, Vestergaard, G., Peng, Xu & She, Q., 2015, In: Life. 5, 1, p. 783-817 35 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. 2014
  37. Published

    A novel single-tailed fusiform Sulfolobus virus STSV2 infecting model Sulfolobus species

    Erdmann, S., Chen, B., Huang, X., Deng, Ling, Liu, C., Shah, S. A., Bauer, S. L. M., León Sobrino, C., Wang, H., Wei, Y., She, Q., Garrett, Roger Antony, Huang, L. & Lin, L., 2014, In: Extremophiles. 18, 1, p. 51-60 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Unveiling cell surface and type IV secretion proteins responsible for archaeal rudivirus entry

    Deng, Ling, He, F., Bhoobalan, Yuvaraj, Martinez Alvarez, Laura, Guo, Y. & Peng, Xu, 2014, In: Journal of Virology. 88, 17, p. 10264-10268 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. 2013
  40. Published

    A novel interference mechanism by a type IIIB CRISPR-Cmr module in Sulfolobus

    Deng, Ling, Garrett, Roger Antony, Shah, S. A., Peng, Xu & She, Q., 2013, In: Molecular Microbiology. 87, 5, p. 1088-1099 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Novel insights into gene regulation of the rudivirus SIRV2 infecting Sulfolobus cells

    Okutan, E., Deng, Ling, Mirlashari, S., Uldahl, K., Halim, M., Liu, C., Garrett, Roger Antony, She, Q. & Peng, Xu, 2013, In: R N A Biology. 10, 5, p. 1-11 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. 2012
  43. Published

    A synthetic arabinose-inducible promoter confers high levels of recombinant protein expression in hyperthermophilic archaeon Sulfolobus islandicus

    Peng, N., Deng, Ling, Mei, Y., Jiang, D., Hu, Y., Awayez, M., Liang, Y. & She, Q., 2012, In: Applied and Environmental Microbiology. 78, 16, p. 5630-5637 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Modulation of CRISPR locus transcription by the repeat-binding protein Cbp1 in Sulfolobus

    Deng, Ling, Kenchappa, C. S., Peng, Xu, She, Q. & Garrett, Roger Antony, 2012, In: Nucleic Acids Research. 40, 6, p. 2470-2480 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2011
  46. Published

    CRISPR-based immune systems of the Sulfolobales: complexity and diversity

    Garrett, Roger Antony, Shah, S. A., Vestergaard, G. A., Deng, Ling, Guðbergsdóttir, S. R., Kenchappa, C. S., Erdmann, S. & She, Q., 2011, In: Biochemical Society Transactions. 39, 1, p. 51-57 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Deletion of the topoisomerase III gene in the hyperthermophilic archaeon Sulfolobus islandicus results in slow growth and defects in cell cycle control

    Li, X., Guo, L., Deng, Ling, Feng, D., Ren, Y., Chu, Y., She, Q. & Huang, L., 2011, In: Journal of Genetics and Genomics. 38, 6, p. 253-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

ID: 33281215