Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

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Standard

Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment. / Liu, Zhigang; Dai, Xiaoshuang; Zhang, Hongbo; Shi, Renjie; Hui, Yan; Jin, Xin; Zhang, Wentong; Wang, Luanfeng; Wang, Qianxu; Wang, Danna; Wang, Jia; Tan, Xintong; Ren, Bo; Liu, Xiaoning; Zhao, Tong; Wang, Jiamin; Pan, Junru; Yuan, Tian; Chu, Chuanqi; Lan, Lei; Yin, Fei; Cadenas, Enrique; Shi, Lin; Zhao, Shancen; Liu, Xuebo.

In: Nature Communications, Vol. 11, 855, 2020.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Liu, Z, Dai, X, Zhang, H, Shi, R, Hui, Y, Jin, X, Zhang, W, Wang, L, Wang, Q, Wang, D, Wang, J, Tan, X, Ren, B, Liu, X, Zhao, T, Wang, J, Pan, J, Yuan, T, Chu, C, Lan, L, Yin, F, Cadenas, E, Shi, L, Zhao, S & Liu, X 2020, 'Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment', Nature Communications, vol. 11, 855. https://doi.org/10.1038/s41467-020-14676-4

APA

Liu, Z., Dai, X., Zhang, H., Shi, R., Hui, Y., Jin, X., ... Liu, X. (2020). Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment. Nature Communications, 11, [855]. https://doi.org/10.1038/s41467-020-14676-4

Vancouver

Liu Z, Dai X, Zhang H, Shi R, Hui Y, Jin X et al. Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment. Nature Communications. 2020;11. 855. https://doi.org/10.1038/s41467-020-14676-4

Author

Liu, Zhigang ; Dai, Xiaoshuang ; Zhang, Hongbo ; Shi, Renjie ; Hui, Yan ; Jin, Xin ; Zhang, Wentong ; Wang, Luanfeng ; Wang, Qianxu ; Wang, Danna ; Wang, Jia ; Tan, Xintong ; Ren, Bo ; Liu, Xiaoning ; Zhao, Tong ; Wang, Jiamin ; Pan, Junru ; Yuan, Tian ; Chu, Chuanqi ; Lan, Lei ; Yin, Fei ; Cadenas, Enrique ; Shi, Lin ; Zhao, Shancen ; Liu, Xuebo. / Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment. In: Nature Communications. 2020 ; Vol. 11.

Bibtex

@article{acb847e3793c42e6ad1ae329768175e7,
title = "Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment",
abstract = "Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive. Here, we find that a 28-day IF regimen for diabetic mice improves behavioral impairment via a microbiota-metabolites-brain axis: IF enhances mitochondrial biogenesis and energy metabolism gene expression in hippocampus, re-structures the gut microbiota, and improves microbial metabolites that are related to cognitive function. Moreover, strong connections are observed between IF affected genes, microbiota and metabolites, as assessed by integrative modelling. Removing gut microbiota with antibiotics partly abolishes the neuroprotective effects of IF. Administration of 3-indolepropionic acid, serotonin, short chain fatty acids or tauroursodeoxycholic acid shows a similar effect to IF in terms of improving cognitive function. Together, our study purports the microbiota-metabolites-brain axis as a mechanism that can enable therapeutic strategies against metabolism-implicated cognitive pathophysiologies.",
author = "Zhigang Liu and Xiaoshuang Dai and Hongbo Zhang and Renjie Shi and Yan Hui and Xin Jin and Wentong Zhang and Luanfeng Wang and Qianxu Wang and Danna Wang and Jia Wang and Xintong Tan and Bo Ren and Xiaoning Liu and Tong Zhao and Jiamin Wang and Junru Pan and Tian Yuan and Chuanqi Chu and Lei Lan and Fei Yin and Enrique Cadenas and Lin Shi and Shancen Zhao and Xuebo Liu",
year = "2020",
doi = "10.1038/s41467-020-14676-4",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

AU - Liu, Zhigang

AU - Dai, Xiaoshuang

AU - Zhang, Hongbo

AU - Shi, Renjie

AU - Hui, Yan

AU - Jin, Xin

AU - Zhang, Wentong

AU - Wang, Luanfeng

AU - Wang, Qianxu

AU - Wang, Danna

AU - Wang, Jia

AU - Tan, Xintong

AU - Ren, Bo

AU - Liu, Xiaoning

AU - Zhao, Tong

AU - Wang, Jiamin

AU - Pan, Junru

AU - Yuan, Tian

AU - Chu, Chuanqi

AU - Lan, Lei

AU - Yin, Fei

AU - Cadenas, Enrique

AU - Shi, Lin

AU - Zhao, Shancen

AU - Liu, Xuebo

PY - 2020

Y1 - 2020

N2 - Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive. Here, we find that a 28-day IF regimen for diabetic mice improves behavioral impairment via a microbiota-metabolites-brain axis: IF enhances mitochondrial biogenesis and energy metabolism gene expression in hippocampus, re-structures the gut microbiota, and improves microbial metabolites that are related to cognitive function. Moreover, strong connections are observed between IF affected genes, microbiota and metabolites, as assessed by integrative modelling. Removing gut microbiota with antibiotics partly abolishes the neuroprotective effects of IF. Administration of 3-indolepropionic acid, serotonin, short chain fatty acids or tauroursodeoxycholic acid shows a similar effect to IF in terms of improving cognitive function. Together, our study purports the microbiota-metabolites-brain axis as a mechanism that can enable therapeutic strategies against metabolism-implicated cognitive pathophysiologies.

AB - Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive. Here, we find that a 28-day IF regimen for diabetic mice improves behavioral impairment via a microbiota-metabolites-brain axis: IF enhances mitochondrial biogenesis and energy metabolism gene expression in hippocampus, re-structures the gut microbiota, and improves microbial metabolites that are related to cognitive function. Moreover, strong connections are observed between IF affected genes, microbiota and metabolites, as assessed by integrative modelling. Removing gut microbiota with antibiotics partly abolishes the neuroprotective effects of IF. Administration of 3-indolepropionic acid, serotonin, short chain fatty acids or tauroursodeoxycholic acid shows a similar effect to IF in terms of improving cognitive function. Together, our study purports the microbiota-metabolites-brain axis as a mechanism that can enable therapeutic strategies against metabolism-implicated cognitive pathophysiologies.

U2 - 10.1038/s41467-020-14676-4

DO - 10.1038/s41467-020-14676-4

M3 - Journal article

C2 - 32071312

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 855

ER -

ID: 236318395